Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2-difluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | - |
Homo sapiens | |
1-fluoro-5,6,7,8-tetrahydrophenanthrene-3,4-dione | - |
Homo sapiens | |
1-fluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | - |
Homo sapiens | |
1-methyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | - |
Homo sapiens | |
2,6,6-trimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | - |
Homo sapiens | |
2,7,7-trimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | - |
Homo sapiens | |
2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione | - |
Homo sapiens | |
2-fluoro-5,6,7,8-tetrahydrophenanthrene-3,4-dione | - |
Homo sapiens | |
2-fluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | - |
Homo sapiens | |
2-fluorophenanthrene-3,4-dione | - |
Homo sapiens | |
2-methoxy-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | - |
Homo sapiens | |
2-methyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | - |
Homo sapiens | |
5,6,7,8-tetrahydrophenanthrene-3,4-dione | - |
Homo sapiens | |
6,6-dimethyl-2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione | - |
Homo sapiens | |
6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | - |
Homo sapiens | |
7,7-dimethyl-2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione | - |
Homo sapiens | |
8-methyl-1,4-dihydro-2H-naphtho[2,1-c]pyran-9,10-dione | - |
Homo sapiens | |
miltirone | - |
Homo sapiens | |
additional information | synthesis of 1,2-dione-containing abietane analogues for generation of human carboxylesterase inhibitors by a retrosynthetic strategy, molecular docking of ligands to the enzyme's active site, overview | Homo sapiens | |
phenanthrene-3,4-dione | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P23141 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-nitrophenyl acetate + H2O | - |
Homo sapiens | 2-nitrophenol + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HCE1 | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000122 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 2-fluoro-5,6,7,8-tetrahydrophenanthrene-3,4-dione | |
0.0000144 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 1-fluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | |
0.0000251 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 1-methyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | |
0.0000259 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 1-fluoro-5,6,7,8-tetrahydrophenanthrene-3,4-dione | |
0.0000319 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | |
0.000042 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 2-fluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | |
0.0000425 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 2-methoxy-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | |
0.0000487 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 2-fluorophenanthrene-3,4-dione | |
0.000102 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 1,2-difluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | |
0.000131 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 5,6,7,8-tetrahydrophenanthrene-3,4-dione | |
0.000495 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 2,7,7-trimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | |
0.000942 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | phenanthrene-3,4-dione | |
0.001054 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione | |
0.001223 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 2-methyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | |
0.001871 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 6,6-dimethyl-2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione | |
0.002425 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 2,6,6-trimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione | |
0.00253 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | miltirone | |
0.004204 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 7,7-dimethyl-2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione | |
0.01 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 8-methyl-1,4-dihydro-2H-naphtho[2,1-c]pyran-9,10-dione |