Cloned (Comment) | Organism |
---|---|
expressed in Spodoptera frugiperda cells and in U373MG cells | Homo sapiens |
expressed in Spodoptera frugiperda cells and in U373MG cells | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2-dicyclohexylethane-1,2-dione | - |
Homo sapiens | |
1,2-dicyclohexylethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,4-dibromo-1,4-diphenyl butane-2,3-dione | irreversible inhibition | Homo sapiens | |
1,4-dibromo-1,4-diphenyl butane-2,3-dione | irreversible inhibition | Oryctolagus cuniculus | |
benzil | irreversible inhibition | Homo sapiens | |
benzil | irreversible inhibition | Oryctolagus cuniculus | |
decane-5,6-dione | - |
Homo sapiens | |
decane-5,6-dione | - |
Oryctolagus cuniculus | |
dodecane-6,7-dione | - |
Homo sapiens | |
dodecane-6,7-dione | - |
Oryctolagus cuniculus | |
hexadecane-8,9-dione | - |
Homo sapiens | |
hexadecane-8,9-dione | - |
Oryctolagus cuniculus | |
additional information | not inhibited by butane-2,3-dione, hexane 3,4-dione, oxanilide, S1,S2-diphenyl ethane bis(thioate), diphenyl ethanedioate, 1,4-diphenylbutane-2,3-dione, and 1-bromo-1,4-diphenyl butane-2,3-dione | Homo sapiens | |
additional information | not inhibited by butane-2,3-dione, hexane 3,4-dione, oxanilide, S1,S2-diphenyl ethane bis(thioate), diphenyl ethanedioate, 1,4-diphenylbutane-2,3-dione, and 1-bromo-1,4-diphenyl butane-2,3-dione | Oryctolagus cuniculus | |
octadecane-9,10-dione | - |
Homo sapiens | |
octadecane-9,10-dione | - |
Oryctolagus cuniculus | |
octane-4,5-dione | - |
Homo sapiens | |
octane-4,5-dione | - |
Oryctolagus cuniculus | |
phenyl-1,2-butanedione | - |
Homo sapiens | |
phenyl-1,2-butanedione | - |
Oryctolagus cuniculus | |
phenyl-1,2-heptanedione | - |
Homo sapiens | |
phenyl-1,2-heptanedione | - |
Oryctolagus cuniculus | |
phenyl-1,2-hexanedione | - |
Homo sapiens | |
phenyl-1,2-hexanedione | - |
Oryctolagus cuniculus | |
phenyl-1,2-octanedione | - |
Homo sapiens | |
phenyl-1,2-octanedione | - |
Oryctolagus cuniculus | |
phenyl-1,2-pentanedione | - |
Homo sapiens | |
phenyl-1,2-pentanedione | - |
Oryctolagus cuniculus | |
phenyl-1,2-propanedione | - |
Homo sapiens | |
phenyl-1,2-propanedione | - |
Oryctolagus cuniculus | |
tetradecane-7,8-dione | - |
Homo sapiens | |
tetradecane-7,8-dione | - |
Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
liver | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl acetate + H2O | - |
Homo sapiens | 4-methylumbelliferone + acetate | - |
? | |
4-methylumbelliferyl acetate + H2O | - |
Oryctolagus cuniculus | 4-methylumbelliferone + acetate | - |
? | |
4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
? | |
4-nitrophenyl acetate + H2O | - |
Oryctolagus cuniculus | 4-nitrophenol + acetate | - |
? | |
CPT-11 + H2O | - |
Homo sapiens | SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2 | - |
? | |
CPT-11 + H2O | - |
Oryctolagus cuniculus | SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CE1 | carboxylesterase from liver | Homo sapiens |
ICE | carboxylesterase from intestine | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000084 | - |
octadecane-9,10-dione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.00000219 | - |
phenyl-1,2-octanedione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.000003 | - |
dodecane-6,7-dione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.0000048 | - |
tetradecane-7,8-dione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.000005 | - |
1,2-dicyclohexylethane-1,2-dione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.0000057 | - |
octadecane-9,10-dione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.0000065 | - |
hexadecane-8,9-dione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
0.00000665 | - |
phenyl-1,2-heptanedione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.0000076 | - |
hexadecane-8,9-dione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.000009 | - |
octadecane-9,10-dione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
0.000015 | - |
benzil | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.0000151 | - |
tetradecane-7,8-dione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
0.0000205 | - |
1,4-dibromo-1,4-diphenyl butane-2,3-dione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
0.0000256 | - |
hexadecane-8,9-dione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.0000261 | - |
phenyl-1,2-hexanedione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.000027 | - |
1,2-dicyclohexylethane-1,2-dione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
0.0000281 | - |
phenyl-1,2-octanedione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
0.0000287 | - |
phenyl-1,2-octanedione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.0000386 | - |
dodecane-6,7-dione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
0.000045 | - |
benzil | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.0000455 | - |
phenyl-1,2-heptanedione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.0000466 | - |
decane-5,6-dione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.0000577 | - |
dodecane-6,7-dione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.000072 | - |
1,2-dicyclohexylethane-1,2-dione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.0000727 | - |
phenyl-1,2-hexanedione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.0000764 | - |
tetradecane-7,8-dione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.000102 | - |
phenyl-1,2-pentanedione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.000102 | - |
benzil | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
0.00011 | - |
phenyl-1,2-heptanedione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
0.000189 | - |
decane-5,6-dione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.000334 | - |
1,4-dibromo-1,4-diphenyl butane-2,3-dione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.000337 | - |
phenyl-1,2-hexanedione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
0.000401 | - |
phenyl-1,2-pentanedione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.000944 | - |
decane-5,6-dione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
0.00155 | - |
phenyl-1,2-butanedione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.00184 | - |
phenyl-1,2-propanedione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.00242 | - |
phenyl-1,2-butanedione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.00271 | - |
phenyl-1,2-pentanedione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
0.004493 | - |
phenyl-1,2-propanedione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
0.00467 | - |
octane-4,5-dione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.00527 | - |
phenyl-1,2-propanedione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.008 | - |
1,4-dibromo-1,4-diphenyl butane-2,3-dione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.00806 | - |
octane-4,5-dione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
0.0125 | - |
phenyl-1,2-butanedione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
0.01778 | - |
octane-4,5-dione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus |