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Literature summary for 3.1.1.1 extracted from
- Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs (2008), Molecules, 13, 412-431.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| di(2-ethylhexyl)phthalate | induced by di(2-ethylhexyl)phthalate | Mus musculus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| microsome | - |
Cavia porcellus | - |
- |
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Canis lupus familiaris | - |
- |
| microsome | - |
Mesocricetus auratus | - |
- |
| microsome | - |
Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
- |
- |
| Cavia porcellus | - |
- |
- |
| Homo sapiens | P23141 | - |
- |
| Mesocricetus auratus | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | most CES isozymes are glycoproteins, and the carbohydrate chain is required for the enzyme activity | Cavia porcellus |
| glycoprotein | most CES isozymes are glycoproteins, and the carbohydrate chain is required for the enzyme activity | Mus musculus |
| glycoprotein | most CES isozymes are glycoproteins, and the carbohydrate chain is required for the enzyme activity | Rattus norvegicus |
| glycoprotein | most CES isozymes are glycoproteins, and the carbohydrate chain is required for the enzyme activity | Canis lupus familiaris |
| glycoprotein | most CES isozymes are glycoproteins, and the carbohydrate chain is required for the enzyme activity | Mesocricetus auratus |
| glycoprotein | most CES isozymes are glycoproteins, and the carbohydrate chain is required for the enzyme activity | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | CES1 and CES2 are strongly expressed in liver | Mus musculus | - |
| kidney | CES1 but not CES2 is strongly expressed in kidney | Rattus norvegicus | - |
| kidney | CES1 but not CES2 is strongly expressed in kidney | Mesocricetus auratus | - |
| kidney | predominant expression of CES1 in kidney | Cavia porcellus | - |
| kidney | predominant expression of isozyme CES2 | Homo sapiens | - |
| liver | CES1 and CES2 are expressed in liver | Canis lupus familiaris | - |
| liver | CES1 and CES2 are strongly expressed in liver | Mus musculus | - |
| liver | CES1 but not CES2 is expressed in liver | Cavia porcellus | - |
| liver | CES1 but not CES2 is strongly expressed in liver | Rattus norvegicus | - |
| liver | CES1 but not CES2 is strongly expressed in liver | Mesocricetus auratus | - |
| liver | most of all CES1 family, except CES1G, are mainly expressed in liver | Homo sapiens | - |
| lung | CES1 but not CES2 is strongly expressed in lung | Rattus norvegicus | - |
| lung | predominant expression of CES1 in lung | Canis lupus familiaris | - |
| lung | predominant expression of isozyme CES1 | Mus musculus | - |
| lung | predominant expression of isozyme CES1 | Homo sapiens | - |
| additional information | not detected in small intestine | Canis lupus familiaris | - |
| additional information | not expressed in lung | Mesocricetus auratus | - |
| small intestine | CES2 but not CES1 is strongly expressed in small intestine | Rattus norvegicus | - |
| small intestine | CES2 but not CES1 is strongly expressed in small intestine | Mesocricetus auratus | - |
| small intestine | predominant expression of CES1 in small intestine | Cavia porcellus | - |
| small intestine | predominant expression of isozyme CES2 | Mus musculus | - |
| small intestine | predominant expression of isozyme CES2 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl acetate + H2O | - |
Cavia porcellus | 4-nitrophenol + acetate | - |
? | |
| 4-nitrophenyl acetate + H2O | - |
Mus musculus | 4-nitrophenol + acetate | - |
? | |
| 4-nitrophenyl acetate + H2O | - |
Rattus norvegicus | 4-nitrophenol + acetate | - |
? | |
| 4-nitrophenyl acetate + H2O | - |
Canis lupus familiaris | 4-nitrophenol + acetate | - |
? | |
| 4-nitrophenyl acetate + H2O | - |
Mesocricetus auratus | 4-nitrophenol + acetate | - |
? | |
| 4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
? | |
| capecitabin + H2O | - |
Cavia porcellus | ? | - |
? | |
| capecitabin + H2O | - |
Mus musculus | ? | - |
? | |
| capecitabin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| capecitabin + H2O | - |
Canis lupus familiaris | ? | - |
? | |
| capecitabin + H2O | - |
Mesocricetus auratus | ? | - |
? | |
| capecitabin + H2O | - |
Homo sapiens | ? | - |
? | |
| cilazapril + H2O | - |
Cavia porcellus | ? | - |
? | |
| cilazapril + H2O | - |
Mus musculus | ? | - |
? | |
| cilazapril + H2O | - |
Rattus norvegicus | ? | - |
? | |
| cilazapril + H2O | - |
Canis lupus familiaris | ? | - |
? | |
| cilazapril + H2O | - |
Mesocricetus auratus | ? | - |
? | |
| cilazapril + H2O | - |
Homo sapiens | ? | - |
? | |
| cocaine + H2O | specific substrate for isozyme CES1 | Cavia porcellus | ecgonine methyl ester + benzoate | - |
? | |
| cocaine + H2O | specific substrate for isozyme CES1 | Mus musculus | ecgonine methyl ester + benzoate | - |
? | |
| cocaine + H2O | specific substrate for isozyme CES1 | Rattus norvegicus | ecgonine methyl ester + benzoate | - |
? | |
| cocaine + H2O | specific substrate for isozyme CES1 | Canis lupus familiaris | ecgonine methyl ester + benzoate | - |
? | |
| cocaine + H2O | specific substrate for isozyme CES1 | Mesocricetus auratus | ecgonine methyl ester + benzoate | - |
? | |
| cocaine + H2O | specific substrate for isozyme CES1 | Homo sapiens | ecgonine methyl ester + benzoate | - |
? | |
| cocaine + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Cavia porcellus | ecgonine methyl ester + benzoate | - |
? | |
| cocaine + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Mus musculus | ecgonine methyl ester + benzoate | - |
? | |
| cocaine + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Rattus norvegicus | ecgonine methyl ester + benzoate | - |
? | |
| cocaine + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Canis lupus familiaris | ecgonine methyl ester + benzoate | - |
? | |
| cocaine + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Mesocricetus auratus | ecgonine methyl ester + benzoate | - |
? | |
| cocaine + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Homo sapiens | ecgonine methyl ester + benzoate | - |
? | |
| CPT-11 + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Cavia porcellus | SN-38 + ? | - |
? | |
| CPT-11 + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Mus musculus | SN-38 + ? | - |
? | |
| CPT-11 + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Rattus norvegicus | SN-38 + ? | - |
? | |
| CPT-11 + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Canis lupus familiaris | SN-38 + ? | - |
? | |
| CPT-11 + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Mesocricetus auratus | SN-38 + ? | - |
? | |
| CPT-11 + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Homo sapiens | SN-38 + ? | - |
? | |
| heroin + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Cavia porcellus | 6-monoacetylmorphine + acetate | - |
? | |
| heroin + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Mus musculus | 6-monoacetylmorphine + acetate | - |
? | |
| heroin + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Rattus norvegicus | 6-monoacetylmorphine + acetate | - |
? | |
| heroin + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Canis lupus familiaris | 6-monoacetylmorphine + acetate | - |
? | |
| heroin + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Mesocricetus auratus | 6-monoacetylmorphine + acetate | - |
? | |
| heroin + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Homo sapiens | 6-monoacetylmorphine + acetate | - |
? | |
| imidapril + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Cavia porcellus | ? | - |
? | |
| imidapril + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Mus musculus | ? | - |
? | |
| imidapril + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Rattus norvegicus | ? | - |
? | |
| imidapril + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Canis lupus familiaris | ? | - |
? | |
| imidapril + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Mesocricetus auratus | ? | - |
? | |
| imidapril + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Homo sapiens | ? | - |
? | |
| meperidine + H2O | specific substrate for isozyme CES1 | Cavia porcellus | ? | - |
? | |
| meperidine + H2O | specific substrate for isozyme CES1 | Mus musculus | ? | - |
? | |
| meperidine + H2O | specific substrate for isozyme CES1 | Rattus norvegicus | ? | - |
? | |
| meperidine + H2O | specific substrate for isozyme CES1 | Canis lupus familiaris | ? | - |
? | |
| meperidine + H2O | specific substrate for isozyme CES1 | Mesocricetus auratus | ? | - |
? | |
| meperidine + H2O | specific substrate for isozyme CES1 | Homo sapiens | ? | - |
? | |
| methylphenidate + H2O | specific substrate for isozyme CES1 | Cavia porcellus | ? | - |
? | |
| methylphenidate + H2O | specific substrate for isozyme CES1 | Mus musculus | ? | - |
? | |
| methylphenidate + H2O | specific substrate for isozyme CES1 | Rattus norvegicus | ? | - |
? | |
| methylphenidate + H2O | specific substrate for isozyme CES1 | Canis lupus familiaris | ? | - |
? | |
| methylphenidate + H2O | specific substrate for isozyme CES1 | Mesocricetus auratus | ? | - |
? | |
| methylphenidate + H2O | specific substrate for isozyme CES1 | Homo sapiens | ? | - |
? | |
| methylprednisolone 21-hemisuccinate + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Cavia porcellus | ? | - |
? | |
| methylprednisolone 21-hemisuccinate + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Mus musculus | ? | - |
? | |
| methylprednisolone 21-hemisuccinate + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Rattus norvegicus | ? | - |
? | |
| methylprednisolone 21-hemisuccinate + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Canis lupus familiaris | ? | - |
? | |
| methylprednisolone 21-hemisuccinate + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Mesocricetus auratus | ? | - |
? | |
| methylprednisolone 21-hemisuccinate + H2O | the substrate is more specific for isozyme CES2 than for CES1 | Homo sapiens | ? | - |
? | |
| oseltamivir + H2O | specific substrate for isozyme CES1 | Cavia porcellus | ? | - |
? | |
| oseltamivir + H2O | specific substrate for isozyme CES1 | Mus musculus | ? | - |
? | |
| oseltamivir + H2O | specific substrate for isozyme CES1 | Rattus norvegicus | ? | - |
? | |
| oseltamivir + H2O | specific substrate for isozyme CES1 | Canis lupus familiaris | ? | - |
? | |
| oseltamivir + H2O | specific substrate for isozyme CES1 | Mesocricetus auratus | ? | - |
? | |
| oseltamivir + H2O | specific substrate for isozyme CES1 | Homo sapiens | ? | - |
? | |
| quinapril + H2O | - |
Cavia porcellus | ? | - |
? | |
| quinapril + H2O | - |
Mus musculus | ? | - |
? | |
| quinapril + H2O | - |
Rattus norvegicus | ? | - |
? | |
| quinapril + H2O | - |
Canis lupus familiaris | ? | - |
? | |
| quinapril + H2O | - |
Mesocricetus auratus | ? | - |
? | |
| quinapril + H2O | - |
Homo sapiens | ? | - |
? | |
| temocapril + H2O | specific substrate for isozyme CES1 | Cavia porcellus | ? | - |
? | |
| temocapril + H2O | specific substrate for isozyme CES1 | Mus musculus | ? | - |
? | |
| temocapril + H2O | specific substrate for isozyme CES1 | Rattus norvegicus | ? | - |
? | |
| temocapril + H2O | specific substrate for isozyme CES1 | Canis lupus familiaris | ? | - |
? | |
| temocapril + H2O | specific substrate for isozyme CES1 | Mesocricetus auratus | ? | - |
? | |
| temocapril + H2O | specific substrate for isozyme CES1 | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acylcarnitine hydrolase | - |
Mus musculus |
| CES1 | isozyme | Cavia porcellus |
| CES1 | isozyme | Mus musculus |
| CES1 | isozyme | Rattus norvegicus |
| CES1 | isozyme | Canis lupus familiaris |
| CES1 | isozyme | Mesocricetus auratus |
| CES1 | isozyme | Homo sapiens |
| CES2 | isozyme | Cavia porcellus |
| CES2 | isozyme | Mus musculus |
| CES2 | isozyme | Rattus norvegicus |
| CES2 | isozyme | Canis lupus familiaris |
| CES2 | isozyme | Mesocricetus auratus |
| CES2 | isozyme | Homo sapiens |
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