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Literature summary for 3.1.1.1 extracted from

  • Tanino, T.; Nawa, A.; Miki, Y.; Iwaki, M.
    Enzymatic stability of 2-ethylcarbonate-linked paclitaxel in serum and conversion to paclitaxel by rabbit liver carboxylesterase for use in prodrug/enzyme therapy (2008), Biopharm. Drug Dispos., 29, 259-269.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by bis(p-nitrophenyl) phosphate Homo sapiens
additional information not inhibited by bis(p-nitrophenyl) phosphate Oryctolagus cuniculus
additional information not inhibited by bis(p-nitrophenyl) phosphate Rattus norvegicus
Phenylmethyl sulfonylfluoride
-
Homo sapiens
Phenylmethyl sulfonylfluoride
-
Oryctolagus cuniculus
phenylmethylsulfonyl fluoride
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0088
-
2'-ethylcarbonate-linked paclitaxel
-
Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-
microsome
-
Oryctolagus cuniculus
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Oryctolagus cuniculus
-
serum
-
Homo sapiens
-
serum
-
Rattus norvegicus
-
serum
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-ethylcarbonate-linked paclitaxel + H2O
-
Homo sapiens paclitaxel + propanoate
-
?
2'-ethylcarbonate-linked paclitaxel + H2O
-
Rattus norvegicus paclitaxel + propanoate
-
?
2'-ethylcarbonate-linked paclitaxel + H2O
-
Oryctolagus cuniculus paclitaxel + propanoate
-
?

Synonyms

Synonyms Comment Organism
CES
-
Homo sapiens
CES
-
Rattus norvegicus
CES
-
Oryctolagus cuniculus

pH Stability

pH Stability pH Stability Maximum Comment Organism
5 7.4 no degradation activity at pH 5.0, chemically stable at pH 6.0-7.4 Homo sapiens
5 7.4 no degradation activity at pH 5.0, chemically stable at pH 6.0-7.4 Rattus norvegicus
5 7.4 no degradation activity at pH 5.0, chemically stable at pH 6.0-7.4 Oryctolagus cuniculus