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Literature summary for 3.1.1.1 extracted from

  • Stok, J.E.; Huang, H.; Jones, P.D.; Wheelock, C.E.; Morisseau, C.; Hammock, B.D.
    Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes (2004), J. Biol. Chem., 279, 29863-29869.
    View publication on PubMed
Search for more literature for 3.1.1.1

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 expressed in baculoviral system
-
Mus musculus Q8BK48 expressed in baculoviral system
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00094
-
 substrate (2S)-fenvalerate, pH 8.0, 30°C Mus musculus
0.0014
-
 substrate (alphaR)(2S)-fenvalerate, pH 8.0, 30°C Mus musculus
0.0072
-
 substrate (alphaS)(2R)-fenvalerate, pH 8.0, 30°C Mus musculus
0.02
-
 substrate cyano(6-methoxynaphthalen-2-yl)methyl (2S)-2-(4-chlorophenyl)-3-methylbutanoic acid, pH 8.0, 30°C Mus musculus
0.027
-
 substrate cis-permethrin, pH 8.0, 30°C Mus musculus
0.029
-
 substrate (2R)-fenvalerate, pH 8.0, 30°C Mus musculus
0.029
-
 substrate cyano(6-methoxy-2-naphthyl)methyl butanoate, pH 8.0, 30°C Mus musculus
0.045
-
 substrate alpha-cypermethrin, pH 8.0, 30°C Mus musculus
0.06
-
 substrate cis-cypermethrin, pH 8.0, 30°C Mus musculus
0.061
-
 substrate cyano(6-methoxy-2-naphthyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate, pH 8.0, 30°C Mus musculus
0.075
-
 substrate (alphaR)(2R)-fenvalerate, pH 8.0, 30°C Mus musculus
0.095
-
 substrate epsilon-cypermethrin, pH 8.0, 30°C Mus musculus
0.239
-
 substrate permethrin, pH 8.0, 30°C Mus musculus
0.246
-
 substrate trans-cypermethrin, pH 8.0, 30°C Mus musculus
0.597
-
 substrate trans-permethrin, pH 8.0, 30°C Mus musculus
17
-
 substrate 4-nitrophenyl acetate, pH 8.0, 30°C Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2R)-fenvalerate + H2O
-
 Mus musculus ?
-
 ?
(2S)-fenvalerate + H2O
-
 Mus musculus ?
-
 ?
(alphaR)(2R)-fenvalerate + H2O
-
 Mus musculus ?
-
 ?
(alphaR)(2S)-fenvalerate + H2O
-
 Mus musculus ?
-
 ?
(alphaS)(2R)-fenvalerate + H2O
-
 Mus musculus ?
-
 ?
4-nitrophenyl acetate + H2O
-
 Mus musculus 4-nitrophenol + acetate
-
 ?
alpha-cypermethrin + H2O
-
 Mus musculus ?
-
 ?
cis-cypermethrin + H2O
-
 Mus musculus ?
-
 ?
cis-permethrin + H2O
-
 Mus musculus ?
-
 ?
cyano(6-methoxy-2-naphthyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
-
 Mus musculus hydroxy(6-methoxy-2-naphthyl)acetonitrile + 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
-
 ?
cyano(6-methoxy-2-naphthyl)methyl butanoate + H2O
-
 Mus musculus hydroxy(6-methoxy-2-naphthyl)acetonitrile + butanoate
-
 ?
cyano(6-methoxynaphthalen-2-yl)methyl (2S)-2-(4-chlorophenyl)-3-methylbutanoic acid + H2O
-
 Mus musculus (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + hydroxy(6-methoxy-2-naphthyl)acetonitrile
-
 ?
cypermethrin + H2O
-
 Mus musculus ?
-
 ?
epsilon-cypermethrin + H2O
-
 Mus musculus ?
-
 ?
permethrin + H2O
-
 Mus musculus ?
-
 ?
trans-cypermethrin + H2O
-
 Mus musculus ?
-
 ?
trans-permethrin + H2O
-
 Mus musculus ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.067
-
 cyano(6-methoxynaphthalen-2-yl)methyl (2S)-2-(4-chlorophenyl)-3-methylbutanoic acid pH 8.0, 30°C Mus musculus
0.099
-
 cyano(6-methoxy-2-naphthyl)methyl butanoate pH 8.0, 30°C Mus musculus
0.11
-
 cyano(6-methoxy-2-naphthyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate pH 8.0, 30°C Mus musculus
0.12
-
 cypermethrin pH 8.0, 30°C Mus musculus
94
-
 4-nitrophenyl acetate pH 8.0, 30°C Mus musculus