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Literature summary for 3.1.1.1 extracted from
- Characterization of CPT-11 converting carboxylesterase activity in colon tumor and normal tissues: comparison with p-nitro-phenylacetate converting carboxylesterase activity (2000), Anticancer Drugs, 11, 465-470.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Homo sapiens | |
| 0.0034 | - |
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin | liver, pH 7.5, 37°C | Homo sapiens |  |
| 0.0038 | - |
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin | colon carcinoma, pH 7.5, 37°C | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O | Homo sapiens | i.e. CPT-11 or irinotecan, a commercial topoisomerase I inhibitor commonly used for treatment of colorectal tumors | 7-ethyl-10-hydroxy-camptothecin + ? | i.e. SN-38 | ? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colon carcinoma cell | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
? | |
| 7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O | i.e. CPT-11 or irinotecan, a commercial topoisomerase I inhibitor commonly used for treatment of colorectal tumors | Homo sapiens | 7-ethyl-10-hydroxy-camptothecin + ? | i.e. SN-38 | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CE | - |
Homo sapiens |
| CPT-CE | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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