BRENDA - Enzyme Database
show all sequences of 2.9.1.1

New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea

Xu, X.M.; Carlson, B.A.; Zhang, Y.; Mix, H.; Kryukov, G.V.; Glass, R.S.; Berry, M.J.; Gladyshev, V.N.; Hatfield, D.L.; Biol. Trace Elem. Res. 119, 234-241 (2007)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene secS, DNA and amino acid sequence determination and analysis
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
soluble
-
Homo sapiens
-
-
soluble
-
Mus musculus
-
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
48000
-
x * 48000, SDS-PAGE
Homo sapiens
48000
-
x * 48000, SDS-PAGE
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-seryl-tRNASec + selenophosphate
Mus musculus
sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview
L-selenocysteinyl-tRNASec + phosphate
-
-
?
L-seryl-tRNASec + selenophosphate
Homo sapiens
sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview
L-selenocysteinyl-tRNASec + phosphate
-
-
?
additional information
Homo sapiens
SecS occurs in patients with autoimmune chronic hepatitis as an autoimmune factor that co-precipitated tRNA[Ser]Sec in cell extracts of these individuals andis known as the SLA, soluble liver antigen
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
liver
-
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-seryl-tRNASec + selenophosphate
-
691179
Homo sapiens
L-selenocysteinyl-tRNASec + phosphate
-
-
-
?
L-seryl-tRNASec + selenophosphate
sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview
691179
Mus musculus
L-selenocysteinyl-tRNASec + phosphate
-
-
-
?
L-seryl-tRNASec + selenophosphate
sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview
691179
Homo sapiens
L-selenocysteinyl-tRNASec + phosphate
-
-
-
?
L-seryl-tRNASec + selenophosphate
the efficiency of tRNA binding in descending order is O-phosphoseryl-tRNA[Ser]Sec, tRNA[Ser]Sec, and seryl-tRNA[Ser]Sec, whereas seryl-tRNASer and tRNASer do not bind at all
691179
Mus musculus
L-selenocysteinyl-tRNASec + phosphate
-
-
-
?
additional information
SecS occurs in patients with autoimmune chronic hepatitis as an autoimmune factor that co-precipitated tRNA[Ser]Sec in cell extracts of these individuals andis known as the SLA, soluble liver antigen
691179
Homo sapiens
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
?
x * 48000, SDS-PAGE
Homo sapiens
?
x * 48000, SDS-PAGE
Mus musculus
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
SecS is a a PLP-dependent transferase
Homo sapiens
pyridoxal 5'-phosphate
SecS is a a PLP-dependent transferase
Mus musculus
Cloned(Commentary) (protein specific)
Commentary
Organism
gene secS, DNA and amino acid sequence determination and analysis
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
SecS is a a PLP-dependent transferase
Homo sapiens
pyridoxal 5'-phosphate
SecS is a a PLP-dependent transferase
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
soluble
-
Homo sapiens
-
-
soluble
-
Mus musculus
-
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
48000
-
x * 48000, SDS-PAGE
Homo sapiens
48000
-
x * 48000, SDS-PAGE
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-seryl-tRNASec + selenophosphate
Mus musculus
sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview
L-selenocysteinyl-tRNASec + phosphate
-
-
?
L-seryl-tRNASec + selenophosphate
Homo sapiens
sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview
L-selenocysteinyl-tRNASec + phosphate
-
-
?
additional information
Homo sapiens
SecS occurs in patients with autoimmune chronic hepatitis as an autoimmune factor that co-precipitated tRNA[Ser]Sec in cell extracts of these individuals andis known as the SLA, soluble liver antigen
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
liver
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-seryl-tRNASec + selenophosphate
-
691179
Homo sapiens
L-selenocysteinyl-tRNASec + phosphate
-
-
-
?
L-seryl-tRNASec + selenophosphate
sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview
691179
Mus musculus
L-selenocysteinyl-tRNASec + phosphate
-
-
-
?
L-seryl-tRNASec + selenophosphate
sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview
691179
Homo sapiens
L-selenocysteinyl-tRNASec + phosphate
-
-
-
?
L-seryl-tRNASec + selenophosphate
the efficiency of tRNA binding in descending order is O-phosphoseryl-tRNA[Ser]Sec, tRNA[Ser]Sec, and seryl-tRNA[Ser]Sec, whereas seryl-tRNASer and tRNASer do not bind at all
691179
Mus musculus
L-selenocysteinyl-tRNASec + phosphate
-
-
-
?
additional information
SecS occurs in patients with autoimmune chronic hepatitis as an autoimmune factor that co-precipitated tRNA[Ser]Sec in cell extracts of these individuals andis known as the SLA, soluble liver antigen
691179
Homo sapiens
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 48000, SDS-PAGE
Homo sapiens
?
x * 48000, SDS-PAGE
Mus musculus
Other publictions for EC 2.9.1.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738683
Manhas
Leishmania donovani encodes a ...
Leishmania donovani
J. Biol. Chem.
291
1203-1220
2016
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1
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6
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1
1
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725024
Manzine
Assembly stoichiometry of bact ...
Escherichia coli
FEBS Lett.
587
906-911
2013
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1
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3
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1
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1
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1
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739586
Manzine
An efficient protocol for the ...
Escherichia coli
Protein Expr. Purif.
88
80-84
2013
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1
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2
1
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2
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1
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1
1
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1
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1
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1
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1
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739706
Itoh
Decameric SelA-tRNA(Sec) ring ...
Aquifex aeolicus
Science
340
75-78
2013
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1
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1
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1
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1
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1
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1
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693212
Ganichkin
Structure and catalytic mechan ...
Mus musculus
J. Biol. Chem.
283
5849-5865
2008
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1
1
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2
1
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5
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1
1
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3
2
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3
2
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691146
Fischer
Towards understanding selenocy ...
Moorella thermoacetica
Biol. Chem.
388
1061-1067
2007
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1
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1
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2
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7
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2
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1
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3
2
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691179
Xu
New developments in selenium b ...
Homo sapiens, Mus musculus
Biol. Trace Elem. Res.
119
234-241
2007
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1
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2
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2
3
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6
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6
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2
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2
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6
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5
2
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660828
Gursinsky
A selDABC cluster for selenocy ...
Peptoclostridium acidaminophilum
Arch. Microbiol.
174
200-212
2000
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1
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1
1
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661290
Mizutani
Selenophosphate as a substrate ...
Bos taurus
Biofactors
9
27-36
1999
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1
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5
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22917
Tormay
Bacterial selenocysteine synth ...
Desulfomicrobium baculatum, Escherichia coli, Haemophilus influenzae, Moorella thermoacetica
Eur. J. Biochem.
254
655-661
1998
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2
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2
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8
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7
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22916
Tanabe
-
Selenophosphate as a substrate ...
Bos taurus
Nucleic acids Symp. Ser.
35
287-288
1996
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22915
Engelhardt
Structure of selenocysteine sy ...
Escherichia coli
Mol. Microbiol.
6
3461-3467
1992
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22912
Forchhammer
Selenocysteine synthase from E ...
Escherichia coli
J. Biol. Chem.
266
6324-6328
1991
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22913
Forchhammer
Selenocysteine synthase from E ...
Escherichia coli
J. Biol. Chem.
266
6318-6323
1991
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22914
Forchhammer
The function of selenocysteine ...
Escherichia coli
Biochimie
73
1481-1486
1991
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