Literature summary for 2.8.5.1 extracted from

Brunner, K.; Steiner, E.M.; Reshma, R.S.; Sriram, D.; Schnell, R.; Schneider, G.
Profiling of in vitro activities of urea-based inhibitors against cysteine synthases from Mycobacterium tuberculosis (2017), Bioorg. Med. Chem. Lett., 27, 4582-4587 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-[[(2,5-dimethoxyphenyl)carbamoyl]amino]benzoic acid	-	Mycobacterium tuberculosis
3-[(3',4'-dichloro[1,1'-biphenyl]-3-sulfonyl)amino]benzoic acid	-	Mycobacterium tuberculosis
3-[[(3,4-dichlorophenyl)carbamoyl]amino]benzoic acid	-	Mycobacterium tuberculosis
3-[[(4-bromophenyl)carbamoyl]amino]benzoic acid	-	Mycobacterium tuberculosis
3-[[(4-chlorophenyl)carbamoyl]amino]benzoic acid	-	Mycobacterium tuberculosis
3-[[(4-methylphenyl)carbamoyl]amino]benzoic acid	-	Mycobacterium tuberculosis
3-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]benzoic acid	-	Mycobacterium tuberculosis
4-[[(4-bromophenyl)carbamoyl]amino]-2-hydroxybenzoic acid	-	Mycobacterium tuberculosis
4-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]-2-hydroxybenzoic acid	-	Mycobacterium tuberculosis
5-[[(3,4-dichlorophenyl)carbamoyl]amino]-2-hydroxybenzoic acid	-	Mycobacterium tuberculosis
5-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]-2-hydroxybenzoic acid	-	Mycobacterium tuberculosis
N-(3,4-dichlorophenyl)-N'-[3-(1H-tetrazol-5-yl)phenyl]urea	-	Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3-phospho-L-serine + thiosulfate	Mycobacterium tuberculosis	-	S-sulfo-L-cysteine + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-phospho-L-serine + thiosulfate	-	Mycobacterium tuberculosis	S-sulfo-L-cysteine + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
CysK2	-	Mycobacterium tuberculosis

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Mycobacterium tuberculosis

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0066	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	3-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]benzoic acid
0.0101	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	3-[[(3,4-dichlorophenyl)carbamoyl]amino]benzoic acid
0.0103	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	5-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]-2-hydroxybenzoic acid
0.013	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	3-[[(4-chlorophenyl)carbamoyl]amino]benzoic acid
0.0269	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	4-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]-2-hydroxybenzoic acid
0.0276	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	3-[[(4-bromophenyl)carbamoyl]amino]benzoic acid
0.0299	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	5-[[(3,4-dichlorophenyl)carbamoyl]amino]-2-hydroxybenzoic acid

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Release 2023.1 (January 2023)