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Literature summary for 2.8.3.5 extracted from
- 3-Oxoacid CoA transferase 1 as a therapeutic target gene for cisplatin-resistant ovarian cancer (2018), Oncol. Lett., 15, 2611-2618 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene OXCT1 , transient overexpression of OXCT1 in SK-OV-3 OC cells, the level of OXCT1 expresxadsion is increased to 161.5fold in OXCT1-transfected cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | sensitization of cells to cisplatin following overexpression of OXCT1 , overexpression of OXCT1 enhances sensitivity to cisplatin, one of the most effective broad-spectrum anticancer drugs, in the SK-OV-3 OC ovarian cancer cell line. Overexpression of OXCT1 significantly decreases the IC50 for cisplatin by about 21% compared with EGFP-transfected control cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial matrix | - |
Homo sapiens | 5759 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P55809 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-2780 cell | - |
Homo sapiens | - |
| CAOV-3 cell | - |
Homo sapiens | - |
| OV-90 cell | - |
Homo sapiens | - |
| ovary cancer cell | - |
Homo sapiens | - |
| OVCAR-3 cell | - |
Homo sapiens | - |
| PA-1 cell | - |
Homo sapiens | - |
| SKOV-3 cell | - |
Homo sapiens | - |
| TOV-112D cell | - |
Homo sapiens | - |
| TOV-21G cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinyl-CoA + a 3-oxo acid | - |
Homo sapiens | succinate + a 3-oxoacyl-CoA | - |
? |  |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-oxoacid CoA transferase 1 | - |
Homo sapiens |
| OXCT1 | - |
Homo sapiens |
| OXCT1 encodes 3-oxoacid-coenzyme A transferase 1 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | OXCT1 expression is suppressed by DNA methylation in the cisplatin-resistant group | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | overexpression of OXCT1 enhances sensitivity to cisplatin in the SK-OV-3 OC cell line | Homo sapiens |
| physiological function | 3-oxoacid-CoA transferase 1 (OXCT1) is a homodimeric mitochondrial matrix enzyme that serves a central role in extrahepatic ketone body catabolism (ketone bodies to acetyl-CoA to mitochondrial tricarboxylic acid cycle entrance). OXCT1 overexpression in a cisplatin-resistant cell line improves sensitivity to cisplatin. Natural sensitivity to cisplatin is observed in the eight human ovarian cell lines SK-OV-3, PA-1, Caov-3, TOV-21 G, TOV-112D, OV-90, OVCAR-3 and A2780 | Homo sapiens |
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