Any feedback?
Literature summary for 2.8.3.5 extracted from
- Comparative studies on 3-oxo acid coenzyme A transferase from various rat tissues (1974), Biochem. J., 142, 619-627.
General Stability
| General Stability | Organism |
|---|---|
| deoxycholate does not stabilize | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| succinate | product inhibition | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.2 | - |
acetoacetate | heart, succinyl CoA as second substrate | Rattus norvegicus | |
| 0.21 | - |
acetoacetate | kidney, skeletal muscle, pH 8.1, 25°C | Rattus norvegicus | |
| 0.31 | - |
acetoacetate | brain, pH 8.1, 25°C | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | predominantly | Rattus norvegicus | 5739 | - |
| additional information | subcellular distribution | Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 100000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinyl-CoA + acetoacetate | Rattus norvegicus | ketolytic enzyme, uniquely involved in complete oxidation of ketone bodies | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male adult Buffalo | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| homogeneity | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| skeletal muscle | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinyl-CoA + acetoacetate | - |
Rattus norvegicus | succinate + acetoacetyl-CoA | - |
r | |
| succinyl-CoA + acetoacetate | ketolytic enzyme, uniquely involved in complete oxidation of ketone bodies | Rattus norvegicus | ? | - |
? | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Rattus norvegicus | heart enzyme, pH gradient 7-9 | - |
6.8 |
| Rattus norvegicus | kidney, brain, muscle and liver enzyme, pH gradient 7-9 | - |
7.6 |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
