BRENDA - Enzyme Database
show all sequences of 2.8.3.18

Anaerobic pyruvate metabolism of Tritrichomonas foetus and Trichomonas vaginalis hydrogenosomes

Steinbüchel, A.; Müller, M.; Mol. Biochem. Parasitol. 20, 57-65 (1986)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.045
-
succinate
pH 7.0, 30°C
Tritrichomonas foetus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
hydrogenosome
-
Tritrichomonas foetus
42566
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Tritrichomonas foetus
-
-
-
Tritrichomonas foetus ATCC 30924
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + succinate
-
723135
Tritrichomonas foetus
succinyl-CoA + acetate
-
-
-
r
acetyl-CoA + succinate
-
723135
Tritrichomonas foetus ATCC 30924
succinyl-CoA + acetate
-
-
-
r
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.045
-
succinate
pH 7.0, 30°C
Tritrichomonas foetus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
hydrogenosome
-
Tritrichomonas foetus
42566
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + succinate
-
723135
Tritrichomonas foetus
succinyl-CoA + acetate
-
-
-
r
acetyl-CoA + succinate
-
723135
Tritrichomonas foetus ATCC 30924
succinyl-CoA + acetate
-
-
-
r
General Information
General Information
Commentary
Organism
physiological function
low concentrations of succinate stimulate the anaerobic pyruvate metabolism of hydrogenosomes. A major function of succinate may be the intraorganellar shuttling of CoA from acetate to succinate as complied by acetate/succinate CoA-transferase
Tritrichomonas foetus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
low concentrations of succinate stimulate the anaerobic pyruvate metabolism of hydrogenosomes. A major function of succinate may be the intraorganellar shuttling of CoA from acetate to succinate as complied by acetate/succinate CoA-transferase
Tritrichomonas foetus
Other publictions for EC 2.8.3.18
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738287
Murphy
Functional dissection of the b ...
Acetobacter aceti 1023, Acetobacter aceti
Front. Chem.
4
23
2016
-
-
1
1
1
-
-
-
-
-
-
2
-
4
-
-
-
-
-
-
-
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2
-
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-
-
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-
-
-
-
-
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1
-
1
1
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-
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2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
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-
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-
-
-
-
-
-
721675
Mullins
Crystal structures of Acetobac ...
Acetobacter aceti 1023, Acetobacter aceti
Biochemistry
51
8422-8434
2012
-
-
1
1
7
-
3
1
-
-
-
1
-
4
-
-
-
1
-
-
-
-
20
-
1
-
-
-
1
-
2
-
3
-
-
-
-
1
-
1
7
-
-
3
3
1
-
-
-
1
-
-
-
-
-
-
-
-
20
-
1
-
-
-
1
-
2
-
-
3
3
-
25
25
692865
Mullins
A specialized citric acid cycl ...
Acetobacter aceti
J. Bacteriol.
190
4933-4940
2008
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-
1
-
-
-
3
8
-
-
2
-
-
2
-
-
1
1
-
-
4
-
6
1
1
-
-
7
1
-
-
-
5
1
-
-
-
2
-
-
-
-
-
5
8
12
-
-
2
-
-
-
-
1
-
-
4
-
6
1
1
-
-
12
1
-
-
1
-
1
1
-
5
5
693049
van Grinsven
Acetate:succinate CoA-transfer ...
Trichomonas vaginalis
J. Biol. Chem.
283
1411-1418
2008
-
-
1
-
-
-
-
1
1
-
1
-
-
6
-
-
-
-
-
-
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
662286
Riviere
Acetyl:succinate CoA-transfera ...
Trypanosoma brucei
J. Biol. Chem.
279
45337-45346
2004
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1
1
-
-
-
-
-
-
-
1
1
-
2
-
-
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1
3
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
3
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723135
Steinbüchel
Anaerobic pyruvate metabolism ...
Tritrichomonas foetus, Tritrichomonas foetus ATCC 30924
Mol. Biochem. Parasitol.
20
57-65
1986
-
-
-
-
-
-
-
1
1
-
-
-
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2
-
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-
-
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2
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1
1
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2
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-
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1
1
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