Cloned (Comment) | Organism |
---|---|
- |
Cupriavidus necator |
Protein Variants | Comment | Organism |
---|---|---|
E342Q | the mutant shows 10% of wild type activity | Cupriavidus necator |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.3 | - |
propionyl-CoA | at pH 7.4 and 30°C | Cupriavidus necator | |
0.6 | - |
acetyl-CoA | at pH 7.4 and 30°C | Cupriavidus necator | |
4.5 | - |
acetate | at pH 7.4 and 30°C | Cupriavidus necator | |
4.5 | - |
3-hydroxybutyrate | at pH 7.4 and 30°C | Cupriavidus necator |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + propanoate | Cupriavidus necator | 100% activity | acetate + propanoyl-CoA | - |
? | |
acetyl-CoA + propanoate | Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1 | 100% activity | acetate + propanoyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cupriavidus necator | - |
- |
- |
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Cupriavidus necator |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxybutyryl-CoA + propanoate | highest rate of reaction with 3-hydroxybutyryl-CoA (100% activity) | Cupriavidus necator | ? | - |
? | |
acetyl-CoA + 3-hydroxybutyrate | - |
Cupriavidus necator | acetate + 3-hydroxybutyryl-CoA | - |
? | |
acetyl-CoA + 3-hydroxybutyrate | - |
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1 | acetate + 3-hydroxybutyryl-CoA | - |
? | |
acetyl-CoA + 3-hydroxypropanoate | - |
Cupriavidus necator | acetate + 3-hydroxypropanoyl-CoA | - |
? | |
acetyl-CoA + 4-hydroxybutyrate | - |
Cupriavidus necator | acetate + 4-hydroxybutyryl-CoA | - |
? | |
acetyl-CoA + acetoacetate | - |
Cupriavidus necator | acetate + acetoacetyl-CoA | - |
? | |
acetyl-CoA + acetoacetate | - |
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1 | acetate + acetoacetyl-CoA | - |
? | |
acetyl-CoA + acrylate | - |
Cupriavidus necator | acetate + acryloyl-CoA | - |
? | |
acetyl-CoA + acrylate | - |
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1 | acetate + acryloyl-CoA | - |
? | |
acetyl-CoA + butyrate | - |
Cupriavidus necator | acetate + butyryl-CoA | - |
? | |
acetyl-CoA + chloropropionate | - |
Cupriavidus necator | acetate + chloropropionyl-CoA | - |
? | |
acetyl-CoA + crotonate | - |
Cupriavidus necator | acetate + crotonoyl-CoA | - |
? | |
acetyl-CoA + glycolate | no activity at 1 mM and 1% activity at 20 mM compared to propanoate | Cupriavidus necator | acetate + glycolyl-CoA | - |
? | |
acetyl-CoA + hexanoate | 4% activity at 1 mM and 21% activity at 20 mM compared to propanoate | Cupriavidus necator | acetate + hexanoyl-CoA | - |
? | |
acetyl-CoA + isobutyrate | isobutyrate is preferentially used as CoA acceptor (34% activity at 1n mM and 100% activity at 20 mM compared to propanoate) | Cupriavidus necator | acetate + isobutyryl-CoA | - |
? | |
acetyl-CoA + isovalerate | 2% activity at 1 mM and 6% activity at 20 mM compared to propanoate | Cupriavidus necator | acetate + isovaleryl-CoA | - |
? | |
acetyl-CoA + lactate | - |
Cupriavidus necator | acetate + lactoyl-CoA | - |
? | |
acetyl-CoA + octanoate | 8% activity at 1 mM and 35% activity at 20 mM compared to propanoate | Cupriavidus necator | acetate + octanoyl-CoA | - |
? | |
acetyl-CoA + propanoate | 100% activity | Cupriavidus necator | acetate + propanoyl-CoA | - |
? | |
acetyl-CoA + propanoate | 100% activity | Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1 | acetate + propanoyl-CoA | - |
? | |
acetyl-CoA + succinate | - |
Cupriavidus necator | acetate + succinoyl-CoA | - |
? | |
acetyl-CoA + trans-2,3-octenoate | 1% activity at 1 mM and 5% activity at 20 mM compared to propanoate | Cupriavidus necator | acetate + trans-2,3-octenoyl-CoA | - |
? | |
acetyl-CoA + trans-2,3-pentenoate | 5% activity at 1 mM and 34% activity at 20 mM compared to propanoate | Cupriavidus necator | acetate + trans-2,3-pentenoyl-CoA | - |
? | |
acetyl-CoA + valerate | 14% activity at 1 mM and 41% activity at 20 mM compared to propanoate | Cupriavidus necator | acetate + valeryl-CoA | - |
? | |
butyryl-CoA + propanoate | 2% activity compared to 3-hydroxybutyryl-CoA | Cupriavidus necator | ? | - |
? | |
crotonyl-CoA + propanoate | 2% activity compared to 3-hydroxybutyryl-CoA | Cupriavidus necator | ? | - |
? | |
isobutyryl-CoA + propanoate | 6% activity compared to 3-hydroxybutyryl-CoA | Cupriavidus necator | ? | - |
? | |
additional information | no activity with acetyl-CoA and formiate, acetoacetate, bromopropionate, glycine, pyruvate, 2-hydroxybutyrate, malonate, fumarate, itaconate, beta-alanine, gamma-aminobutyrate, levulate, glutarate or adipate as potential CoA acceptor. No activity with isovaleryl-CoA as CoA donor | Cupriavidus necator | ? | - |
? | |
additional information | no activity with acetyl-CoA and formiate, acetoacetate, bromopropionate, glycine, pyruvate, 2-hydroxybutyrate, malonate, fumarate, itaconate, beta-alanine, gamma-aminobutyrate, levulate, glutarate or adipate as potential CoA acceptor. No activity with isovaleryl-CoA as CoA donor | Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1 | ? | - |
? | |
propionyl-CoA + propanoate | 27% activity compared to 3-hydroxybutyryl-CoA | Cupriavidus necator | ? | - |
? | |
succinyl-CoA + propanoate | 1% activity compared to 3-hydroxybutyryl-CoA | Cupriavidus necator | ? | - |
? | |
valeryl-CoA + propanoate | 3% activity compared to 3-hydroxybutyryl-CoA | Cupriavidus necator | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PCT | - |
Cupriavidus necator |
propionate CoA-transferase | - |
Cupriavidus necator |