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Literature summary for 2.8.2.B5 extracted from

  • Funabashi, M.; Baba, S.; Nonaka, K.; Hosobuchi, M.; Fujita, Y.; Shibata, T.; Van Lanen, S.G.
    The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase (2010), Chembiochem, 11, 184-190.
    View publication on PubMed
Search for more literature for 2.8.2.B5

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Streptomyces sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
an aryl sulfate + desulfo-A-90289A Streptomyces sp. LipB is a sulfotransferase involved in A-90289 biosynthesis. Sulfate incorporation by LipB might represent a self resistance strategy that leads to inactivation of the antibiotic A-90289s and lipsodiomycins a phenol + A-90289A
-
 ?
an aryl sulfate + desulfo-A-90289A Streptomyces sp. SANK 60405 LipB is a sulfotransferase involved in A-90289 biosynthesis. Sulfate incorporation by LipB might represent a self resistance strategy that leads to inactivation of the antibiotic A-90289s and lipsodiomycins a phenol + A-90289A
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces sp. D4QF15
-
-
Streptomyces sp. SANK 60405 D4QF15
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Streptomyces sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl sulfate + desulfo-A-90289A sulfate transfer occurs at the 2’-hydroxyl. The enzyme shows no activity with 3'-phosphoadenylyl sulfate Streptomyces sp. 4-nitrophenol + A-90289A
-
 ?
4-nitrophenyl sulfate + desulfo-A-90289A sulfate transfer occurs at the 2’-hydroxyl. The enzyme shows no activity with 3'-phosphoadenylyl sulfate Streptomyces sp. SANK 60405 4-nitrophenol + A-90289A
-
 ?
an aryl sulfate + desulfo-A-90289A LipB is a sulfotransferase involved in A-90289 biosynthesis. Sulfate incorporation by LipB might represent a self resistance strategy that leads to inactivation of the antibiotic A-90289s and lipsodiomycins Streptomyces sp. a phenol + A-90289A
-
 ?
an aryl sulfate + desulfo-A-90289A LipB is a sulfotransferase involved in A-90289 biosynthesis. Sulfate incorporation by LipB might represent a self resistance strategy that leads to inactivation of the antibiotic A-90289s and lipsodiomycins Streptomyces sp. SANK 60405 a phenol + A-90289A
-
 ?

Synonyms

Synonyms Comment Organism
LipB ambiguous Streptomyces sp.

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Streptomyces sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Streptomyces sp.

General Information

General Information Comment Organism
malfunction the DELTALipB mutant strain produces desulfo-A-90289s Streptomyces sp.
physiological function LipB is a sulfotransferase involved in A-90289 biosynthesis. Sulfate incorporation by LipB might represent a self resistance strategy that leads to inactivation of the antibiotic A-90289s and lipsodiomycins Streptomyces sp.