Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5,5'-dithiobis(2-nitrobenzoate) | low concentrations lead to increase of activity at a physiological pH, higher concentrations lead to complete inactivation | Rattus norvegicus | |
Diamide | low concentrations lead to increase of activity at a physiological pH, higher concentrations lead to complete inactivation | Rattus norvegicus | |
glutathione disulfide | leads to the formation of internal disulfide bonds between Cys66 and Cys232, activates the enzyme and allows it to function at a pH optimum in the physiological range | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
C232S | mutant is catalytically active | Rattus norvegicus |
C66S | mutant is catalytically active, can not be activated by glutathione disulfide | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Phenylarsine oxide | effective inhibitor | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + 2-naphthol | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + 2-naphthyl sulfate | - |
? | |
3'-phosphoadenylylsulfate + 4-nitrophenol | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
pH optima for sulfation are dependent on the oxidation state of the sulfotransferase | Rattus norvegicus |
5.4 | - |
- |
Rattus norvegicus |
6 | - |
two optima: pH 6 and pH 9.7, reduced enzyme activity with 2-naphthylamine as substrate | Rattus norvegicus |
8 | - |
oxidized enzyme | Rattus norvegicus |
9.7 | - |
two optima: pH 6 and pH 9.7, reduced activity with 2-naphthylamine as substrate | Rattus norvegicus |