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Literature summary for 2.8.2.9 extracted from

  • Mattock, P.; Barford, D.J.; Basford, J.M.; Jones, J.G.
    The effect of substrate concentration and pH on the enzymic sulphation of L-tyrosyl derivatives (1970), Biochem. J., 116, 805-810.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.9

Inhibitors

Inhibitors Comment Organism Structure
iodoacetamide pH 7.5, 30°C, inhibition prevented by presence of 3'-phosphate 5'-sulfatophosphate but not by L-tyrosine methyl ester Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000008
-
 adenosine 3'-phosphate 5'-sulfophosphate pH 7.5, 37°C Rattus norvegicus
0.3
-
 L-tyrosine methyl ester pH 7.5, 37°C Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
3'-phosphoadenylyl sulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate random rapid equilibrium bi bi kinetic mechanism Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + L-tyrosine methyl ester
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate
-
 ?
3'-phosphoadenylylsulfate + N-acetyl-L-tyrosine ethyl ester
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + N-acetyl-L-tyrosine O4-sulfate
-
 ?
3'-phosphoadenylylsulfate + tyramine
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
adenosine 3'-phosphate 5'-sulfophosphate + L-tyrosine methyl ester
-
 Rattus norvegicus ?
-
 ?
additional information enzyme is specific for substrate molecules with a free and unprotonated amino group and an unionized hydroxyl group Rattus norvegicus ?
-
 ?