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Literature summary for 2.8.2.7 extracted from
- Dermatan is a better substrate for 4-O-sulfation than chondroitin: Implications in the generation of 4-O-sulfated, L-iduronate-rich galactosaminoglycans (2000), Arch. Biochem. Biophys., 383, 171-177.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.27 | 0.61 | dermatan | pH 6, 37°C, Km value depends on number of disaccharides of the receptor | Homo sapiens |  |
| 1.56 | 4.22 | chondroitin | pH 6, 37°C, Km value depends on number of disaccharides of the receptor | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | enzyme is stimulated at concentrations of 5-20 mM | Homo sapiens | |
| Mg2+ | enzyme is stimulated at concentrations of 5-20 mM | Homo sapiens | |
| Mn2+ | enzyme is stimulated at concentrations of 5-20 mM | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | biosynthesis of dermatan sulfate | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Homo sapiens | - |
| skin | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylylsulfate + chondroitin | incorporates sulfate at C4 and C6 position of N-acetylgalactosamine residues | Homo sapiens | ? | - |
? | |
| 3'-phosphoadenylylsulfate + dermatan | incorporates sulfate exclusively at C4 position of N-acetylgalactosamine residues | Homo sapiens | ? | - |
? | |
| additional information | biosynthesis of dermatan sulfate | Homo sapiens | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
- |
Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 8 | 30% activity at pH 5, 15% activity at pH 8 | Homo sapiens |
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Release 2023.1 (January 2023)
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