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Literature summary for 2.8.2.5 extracted from

  • Izumikawa, T.; Dejima, K.; Watamoto, Y.; Nomura, K.H.; Kanaki, N.; Rikitake, M.; Tou, M.; Murata, D.; Yanagita, E.; Kano, A.; Mitani, S.; Nomura, K.; Kitagawa, H.
    Chondroitin 4-O-sulfotransferase is indispensable for sulfation of chondroitin and plays an important role in maintaining normal life span and oxidative stress responses in nematodes (2016), J. Biol. Chem., 291, 23294-23304.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.5

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-1 cells Caenorhabditis elegans

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Caenorhabditis elegans
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + chondroitin Caenorhabditis elegans
-
 adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
 ?
3'-phosphoadenylyl sulfate + chondroitin Caenorhabditis elegans N2
-
 adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans Q09272
-
-
Caenorhabditis elegans N2 Q09272
-
-

Purification (Commentary)

Purification (Comment) Organism
IgG-Sepharose bead chromatography Caenorhabditis elegans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + chondroitin
-
 Caenorhabditis elegans adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
 ?
3'-phosphoadenylyl sulfate + chondroitin
-
 Caenorhabditis elegans N2 adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
C41C4.1
-
 Caenorhabditis elegans
Chn 4-O-sulfotransferase
-
 Caenorhabditis elegans
chondroitin 4-O-sulfotransferase
-
 Caenorhabditis elegans

General Information

General Information Comment Organism
malfunction enzyme deletion mutants exhibit reduced survival rates after synchronization with sodium hypochlorite Caenorhabditis elegans
physiological function the enzyme plays an important role in protecting nematodes from oxidative stress Caenorhabditis elegans