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Literature summary for 2.8.2.36 extracted from

  • Lamb, S.S.; Patel, T.; Koteva, K.P.; Wright, G.D.
    Biosynthesis of sulfated glycopeptide antibiotics by using the sulfotransferase StaL (2006), Chem. Biol., 13, 171-181.
    View publication on PubMed
Search for more literature for 2.8.2.36

Cloned(Commentary)

Cloned (Comment) Organism
-
 Streptomyces toyocaensis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75000
-
-
 Streptomyces toyocaensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + desulfo-A47934 Streptomyces toyocaensis the enzyme catalyzes the final step in the biosynthesis of the glycopeptide antibiotic A47934 adenosine 3',5'-bisphosphate + A47934 i.e. LY 154989 ?

Organism

Organism UniProt Comment Textmining
Streptomyces toyocaensis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
His6-StaL Streptomyces toyocaensis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + desulfo-A47934 the enzyme catalyzes the final step in the biosynthesis of the glycopeptide antibiotic A47934 Streptomyces toyocaensis adenosine 3',5'-bisphosphate + A47934 i.e. LY 154989 ?
3'-phosphoadenylyl sulfate + desulfo-A47934 100-fold preference for desulfo-A47934 over teicoplanin Streptomyces toyocaensis adenosine 3',5'-bisphosphate + A47934 i.e. LY 154989 ?
3'-phosphoadenylyl sulfate + teicoplanin the sulfated residue of sulfo-teicoplanin is not unambiguously identified. Based on the precedent with the A47934 fragmentation, it is concluded that His6-StaL preferentially sulfates the glycopeptide antibiotics on the N-terminal 4-hydroxy-L-phenylglycine residue Streptomyces toyocaensis adenosine 3',5'-bisphosphate + sulfo-teicoplanin
-
 ?
3'-phosphoadenylyl sulfate + teicoplanin aglycone the sulfated residue of sulfo-teicoplanin is not unambiguously identified. Based on the precedent with the A47934 fragmentation, it is concluded that His6-StaL preferentially sulfates the glycopeptide antibiotics on the N-terminal 4-hydroxy-L-phenylglycine residue Streptomyces toyocaensis adenosine 3',5'-bisphosphate + sulfoteicoplanin aglycone
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Streptomyces toyocaensis

Synonyms

Synonyms Comment Organism
StaL
-
 Streptomyces toyocaensis

General Information

General Information Comment Organism
malfunction no detectable amount of A47934 is present in the extract from Streptomyces toyocaensis DstaL::aac(3)IV Streptomyces toyocaensis
physiological function the enzyme is involved in the biosynthesis of the glycopeptide antibiotic A47934 Streptomyces toyocaensis