Literature summary for 2.8.2.35 extracted from

Zhang, L.; Mueller, T.; Baenziger, J.U.; Janecke, A.R.
Congenital disorders of glycosylation with emphasis on loss of dermatan-4-sulfotransferase (2010), Prog. Mol. Biol. Transl. Sci., 93, 289-307.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	the enzyme catalyzes the 4-O-sulfation of N-acetylgalactosamine in the repeating iduronic acid-alpha-1,3-N-acetylgalactosamine disaccharide sequence to form dermatan sulfate	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme catalyzes the 4-O-sulfation of N-acetylgalactosamine in the repeating iduronic acid-alpha-1,3-N-acetylgalactosamine disaccharide sequence to form dermatan sulfate	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
CHST14	-	Homo sapiens
D4ST1	-	Homo sapiens
dermatan-4-sulfotransferase	-	Homo sapiens
N-acetylgalactosamine 4-O-sulfotransferase 1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	adducted thumb-clubfoot syndrome is caused by homozygous nonsense and missense mutations in CHST14 which encodes N-acetylgalactosamine 4-O-sulfotransferase 1 leading to congenital malformations, contractures of thumbs and feet, and a typical facial appearance	Homo sapiens

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Release 2023.1 (January 2023)