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Literature summary for 2.8.2.35 extracted from

  • Pacheco, B.; Maccarana, M.; Malmström, A.
    Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate (2009), Glycobiology, 19, 1197-1203.
    View publication on PubMed
Search for more literature for 2.8.2.35

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetylgalactosamine Homo sapiens
-
 adenosine 3'-5'-bisphosphate + [dermatan]-4-O-sulfo-N-acetylgalactosamine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NCH0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung fibroblast primary Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetylgalactosamine
-
 Homo sapiens adenosine 3'-5'-bisphosphate + [dermatan]-4-O-sulfo-N-acetylgalactosamine
-
 ?
3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetylgalactosamine dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate Homo sapiens adenosine 3'-5'-bisphosphate + [dermatan]-4-O-sulfo-N-acetylgalactosamine
-
 ?

Synonyms

Synonyms Comment Organism
dermatan 4-O-sulfotransferase 1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens downregulation of D4ST-1 in primary human lung fibroblasts leads to a drastic specific reduction of iduronic acid blocks. No change of epimerase activity is found, indicating that the influence of D4ST-1 on epimerization is not due to an altered expression level of the DS-epimerases. Analysis of the dermatan sulfate chains shows that D4ST-1 is essential for the biosynthesis of the disulfated structure iduronic acid-2-O-sulfate-N-acetylgalactosamine-4-O-sulfate, thus confirmed to be strictly connected with the iduronic acid blocks. Also the biologically important residue hexuronic acid-N-acetylgalactosamine-4,6-O-disulfate considerably decreases after D4ST-1 downregulation down

General Information

General Information Comment Organism
physiological function D4ST-1 is indispensable in the formation of the important functional domains composed of alternating iduronic acid and 4-O-sulfated N-acetylgalactosamine residues (named 4-O-sulfated iduronic acid blocks) in dermatan sulfate and cannot be compensated by other 4-O-sulfotransferases Homo sapiens