Literature summary for 2.8.2.34 extracted from

McKinney, S.C.; Collins, R.H.; Killenberg, P.G.; Lack, L.
Effect of 6-methylene-4-pregnene-3,20-dione treatment on hepatic bile acid sulfotransferase activity in male rats (1986), Biochem. Pharmacol., 35, 1050-1052.

Search for more literature for 2.8.2.34

Activating Compound

Activating Compound	Comment	Organism	Structure
6-methylene-4-pregnene-3,20-dione	activates the hepatic enzyme in sham-operated and castrated male rats, effect is counteracted by 5alpha-dihydrotestosterone	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
5alpha-dihydrotestosterone	inhibits the hepatic enzyme in sham-operated and castrated male rats, prevents activation by 6-methylene-4-pregnene-3,20-dione	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male sprague-dawley rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.000012	-	castrated male rats with 5alpha-dihydrotestosterone, hepatic enzyme	Rattus norvegicus
0.000017	-	sham-operated male rats with 5alpha-dihydrotestosterone, hepatic enzyme	Rattus norvegicus
0.000019	-	sham-operated male rats with 5alpha-dihydrotestosterone and 6-methylene-4-pregnene-3,20-dione, hepatic enzyme	Rattus norvegicus
0.000023	-	sham-operated male rats, hepatic enzyme	Rattus norvegicus
0.000056	-	sham-operated male rats with 6-methylene-4-pregnene-3,20-dione, hepatic enzyme	Rattus norvegicus
0.00006	-	castrated male rats, hepatic enzyme	Rattus norvegicus
0.000083	-	castrated male rats with 6-methylene-4-pregnene-3,20-dione, hepatic enzyme	Rattus norvegicus

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Release 2023.1 (January 2023)