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Literature summary for 2.8.2.33 extracted from

  • Nozaki, H.; Tomoyama, Y.; Takagi, H.; Yokoyama, K.; Yamada, C.; Kaio, K.; Tsukimori, M.; Nagao, K.; Itakura, Y.; Ohtake-Niimi, S.; Nakano, H.; Habuchi, O.
    Inhibition of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase by -D-4-O-sulfo-N-acetylgalactosaminides bearing various hydrophobic aglycons (2010), Glycoconj. J., 27, 237-248.
    View publication on PubMed
Search for more literature for 2.8.2.33

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Rattus norvegicus chondrosarcoma LTC cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(1R,3R,4S)-menthyl 2-acetamido-2-deoxy-4-O-sulfonato-beta-D-galactopyranoside
-
 Homo sapiens
(1S,3S,4R)-menthyl 2-acetamido-2-deoxy-4-O-sulfonato-beta-D-galactopyranoside weak inhibition Homo sapiens
1-naphthyl 2-acetamido-2-deoxy-4-O-sulfonato-beta-D-galactopyranoside
-
 Homo sapiens
17beta-hydroxyestra-1,3,5(10)-trien-3-yl 2-acetamido-2-deoxy-4-O-sulfonato-beta-D-galactopyranoside competitive inhibitor, 40% inhibition at 0.05 mM, nearly complete inhibition at 0.25 mM Homo sapiens
3-hydroxyestra-1,3,5(10)-trien-17beta-yl 2-acetamido-2-deoxy-4-O-sulfonato-beta-D-galactopyranoside
-
 Homo sapiens
4-chlorophenyl 2-acetamido-2-deoxy-4-O-sulfonato-beta-D-galactopyranoside
-
 Homo sapiens
4-fluorophenyl 2-acetamido-2-deoxy-4-O-sulfonato-beta-D-galactopyranoside
-
 Homo sapiens
4-nitrophenyl 2-acetamido-2-deoxy-4-O-sulfonato-beta-D-galactopyranoside
-
 Homo sapiens
benzyl 2-acetamido-2-deoxy-4-O-sulfonato-beta-D-galactopyranoside
-
 Homo sapiens
cholesteryl 2-acetamido-2-deoxy-4-O-sulfonato-beta-D-galactopyranoside
-
 Homo sapiens
cyclohexyl 2-acetamido-2-deoxy-4-O-sulfonato-beta-D-galactopyranoside
-
 Homo sapiens
additional information not inhibited by cyclohexyl 2-acetamido-2,6-dideoxy-4-O-sulfonato-beta-D-galactopyranoside Homo sapiens
octyl 2-acetamido-2-deoxy-4-O-sulfonato-beta-D-galactopyranoside
-
 Homo sapiens
phenyl 2-acetamido-2-deoxy-1-seleno-4-O-sulfonato-beta-D-galactopyranoside
-
 Homo sapiens
phenyl 2-acetamido-2-deoxy-4-O-sulfonato-1-thio-beta-D-galactopyranoside
-
 Homo sapiens
phenyl-beta-D-GalNAc(4SO4)
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + chondroitin sulfate A Homo sapiens
-
 adenosine 3',5'-bisphosphate + chondroitin sulfate E
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + chondroitin sulfate A
-
 Homo sapiens adenosine 3',5'-bisphosphate + chondroitin sulfate E
-
 ?

Synonyms

Synonyms Comment Organism
GalNAc4S-6ST
-
 Homo sapiens
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.008
-
 17beta-hydroxyestra-1,3,5(10)-trien-3-yl 2-acetamido-2-deoxy-4-O-sulfonato-beta-D-galactopyranoside in imidazole-HCl, pH 6.8, at 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.25
-
 in imidazole-HCl, pH 6.8, at 37°C Homo sapiens 4-chlorophenyl 2-acetamido-2-deoxy-4-O-sulfonato-beta-D-galactopyranoside
2.5
-
 in imidazole-HCl, pH 6.8, at 37°C Homo sapiens phenyl-beta-D-GalNAc(4SO4)