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Literature summary for 2.8.2.30 extracted from

  • Weiss, R.J.; Spahn, P.N.; Toledo, A.G.; Chiang, A.W.T.; Kellman, B.P.; Li, J.; Benner, C.; Glass, C.K.; Gordts, P.L.S.M.; Lewis, N.E.; Esko, J.D.
    ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis (2020), Proc. Natl. Acad. Sci. USA, 117, 9311-9317 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.30

Cloned(Commentary)

Cloned (Comment) Organism
gene HS3ST3A1, expression and promoter sequence analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
intracellular
-
 Homo sapiens 5622
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Homo sapiens
-
 adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y663
-
-

Source Tissue

Source Tissue Comment Organism Textmining
connective tissue
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
mast cell high expression level of HS3ST1 and low expression level of ZNF263 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Homo sapiens adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
3O-sulfotransferase
-
 Homo sapiens
glucosaminyl 3-O-sulfotransferase
-
 Homo sapiens
HS3ST
-
 Homo sapiens
HS3ST3A1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis. CRISPR-mediated targeting and siRNA knockdown of ZNF263 in mammalian cell lines and human primary cells leads to dramatically increased expression levels of HS3ST1. LC-MS analysis of lyase-resistant 3-O-sulfated tetrasaccharides derived from ZNF263-/- cells down

General Information

General Information Comment Organism
malfunction enhanced 3-O-sulfation increases binding to antithrombin, which enhances Factor Xa inhibition, and binding of neuropilin-1 Homo sapiens
metabolism ZNF263, a C2H2 zinc finger protein, is a negative transcriptional regulator of heparin and heparan sulfate biosynthesis, which shows distinctively low expression in mast cells compared with other (non-heparin-producing) immune cells. ZNF263 is a transcriptional repressor, and its inactivation or silencing enhances mRNA expression of HS3ST1 (EC 2.8.2.23) and HS3ST3A1, enzymes involved in the formation of binding sites for antithrombin and neuropilin-1 (NRP1) and glycoprotein D of herpes simplex virus, respectively. Heparan sulfate (HS) biosynthetic genes exhibit the ZNF263 consensus motif Homo sapiens