Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a prognostic marker in breast cancer | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine | Homo sapiens | - |
adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
BT-474 cell | - |
Homo sapiens | - |
MCF-10A cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
MDA-MB-453 cell | - |
Homo sapiens | - |
MDA-MB-468 cell | - |
Homo sapiens | - |
SKBR-3 cell | - |
Homo sapiens | - |
T-47D cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine | - |
Homo sapiens | adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3-OST3A | - |
Homo sapiens |
heparan sulfate sulfotransferase 3-OST3A | - |
Homo sapiens |
HS3ST3A | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | 3-OST3A is epigenetically repressed in breast cancer cell lines (except SKBR-3 cells) | down |
General Information | Comment | Organism |
---|---|---|
physiological function | 3-OST3A exerts dual activities acting as tumor-suppressor in MCF-7 and MDA-MB-231 cells, or as an oncogenic factor in SKBR-3 cells | Homo sapiens |