Literature summary for 2.8.2.30 extracted from

Shukla, D.; Liu, J.; Blaiklock, P.; Shworak, N.W.; Bai, X.; Esko, J.D.; Cohen, G.H.; Eisenberg, R.J.; Rosenberg, R.D.; Spear, P.G.
A novel role for the 3-O-sulfated heparan sulfate in Herpes simplex virus 1 entry (1999), Cell, 99, 13-22.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in CHO cells	Homo sapiens
expression in CHO cells	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine	Homo sapiens	3-O-sulfonation of heparan sulfate by isoenzyme 3A and 3B generates binding sites for the HSV-1 glycoprotein gD and initiation of virus entry	adenosine 3',5'-diphosphate + [heparan sulfate]-glucosamine 3-sulfate	-	?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine	Mus musculus	3-O-sulfonation of heparan sulfate by isoenzyme 3A and 3B generates binding sites for the HSV-1 glycoprotein gD and initiation of virus entry	adenosine 3',5'-diphosphate + [heparan sulfate]-glucosamine 3-sulfate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	Q9QZS6	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine	3-O-sulfonation of heparan sulfate by isoenzyme 3A and 3B generates binding sites for the HSV-1 glycoprotein gD and initiation of virus entry	Homo sapiens	adenosine 3',5'-diphosphate + [heparan sulfate]-glucosamine 3-sulfate	-	?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine	3-O-sulfonation of heparan sulfate by isoenzyme 3A and 3B generates binding sites for the HSV-1 glycoprotein gD and initiation of virus entry	Mus musculus	adenosine 3',5'-diphosphate + [heparan sulfate]-glucosamine 3-sulfate	-	?

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Release 2023.1 (January 2023)