Cloned (Comment) | Organism |
---|---|
gD-type-3-OST-4, DNA and amino acid sequence determination and sequence comparisons, neuronal tissue expression analysis, expression in CHO cells | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | transmembrane enzyme with a short cytoplasmic tail at the N-terminus | Drosophila melanogaster | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
49825 | - |
x * 49825, recombinant gD-type-3-OST-4, sequence calculation | Drosophila melanogaster |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine | Drosophila melanogaster | - |
adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate | i.e. HSgD+, 3-O-sulfated motifs that bind the gD envelope protein of Herpes simplex virus 1 mediating the viral cellular entry, overview | ? | |
additional information | Drosophila melanogaster | gD-type-3-OST is essential for a conserved neurogenic signaling pathway regulated by Notch | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
isozymes gD-type-3-OST-4 and gD-type-3-OST-1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | gD-type-3-OST-4 is one of the major enzymes | Drosophila melanogaster | - |
additional information | neuronal tissue distribution of 3-O-sulfotransferases, overview | Drosophila melanogaster | - |
neuron | of trigeminal ganglia, gD-type-3-OST-2 is one of the major enzymes, highly located in neuronal cell bodies not in axons, overview | Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine | - |
Drosophila melanogaster | adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate | i.e. HSgD+, 3-O-sulfated motifs that bind the gD envelope protein of Herpes simplex virus 1 mediating the viral cellular entry, overview | ? | |
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine | - |
Drosophila melanogaster | adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate | i.e. HSgD+, 3-O-sulfated motifs that bind the gD envelope protein of Herpes simplex virus 1 | ? | |
additional information | gD-type-3-OST is essential for a conserved neurogenic signaling pathway regulated by Notch | Drosophila melanogaster | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 49825, recombinant gD-type-3-OST-4, sequence calculation | Drosophila melanogaster |
More | gD-type-3-OST-4 contains a short N-terminal cytoplasmic tail, a hydrophobic membrane spanning segment, and a SPLAG domain, the cytoplasmic tail contains a polyproline stretch, possibly involved in protein-protein interactions | Drosophila melanogaster |
Synonyms | Comment | Organism |
---|---|---|
gD-type 3-O-sulfotransferase-4 | - |
Drosophila melanogaster |
gD-type-3-OST-1 | - |
Drosophila melanogaster |
gD-type-3-OST-4 | - |
Drosophila melanogaster |
More | the enzyme belongs to the family of 3-O-sulfotransferases | Drosophila melanogaster |