Literature summary for 2.8.2.22 extracted from

Wiker, F.; Konnerth, M.; Helmle, I.; Kulik, A.; Kaysser, L.; Gross, H.; Gust, B.
Identification of novel alpha-pyrones from Conexibacter woesei serving as sulfate shuttles (2019), ACS Chem. Biol., 14, 1972-1980 .

Organism

Organism	UniProt	Comment	Textmining
Conexibacter woesei	D3FB09	-	-
Conexibacter woesei CIP 108061	D3FB09	-	-
Conexibacter woesei DSM 14684	D3FB09	-	-
Conexibacter woesei ID131577	D3FB09	-	-
Conexibacter woesei JCM 11494	D3FB09	-	-
Conexibacter woesei NBRC 100937	D3FB09	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone A sulfate	-	Conexibacter woesei	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone A	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone A sulfate	-	Conexibacter woesei JCM 11494	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone A	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone A sulfate	-	Conexibacter woesei ID131577	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone A	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone A sulfate	-	Conexibacter woesei CIP 108061	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone A	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone A sulfate	-	Conexibacter woesei DSM 14684	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone A	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone A sulfate	-	Conexibacter woesei NBRC 100937	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone A	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone B sulfate	-	Conexibacter woesei	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone B	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone B sulfate	-	Conexibacter woesei JCM 11494	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone B	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone B sulfate	-	Conexibacter woesei ID131577	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone B	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone B sulfate	-	Conexibacter woesei CIP 108061	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone B	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone B sulfate	-	Conexibacter woesei DSM 14684	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone B	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone B sulfate	-	Conexibacter woesei NBRC 100937	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone B	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone C sulfate	-	Conexibacter woesei	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone C	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone C sulfate	-	Conexibacter woesei JCM 11494	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone C	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone C sulfate	-	Conexibacter woesei ID131577	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone C	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone C sulfate	-	Conexibacter woesei CIP 108061	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone C	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone C sulfate	-	Conexibacter woesei DSM 14684	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone C	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone C sulfate	-	Conexibacter woesei NBRC 100937	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone C	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone D sulfate	-	Conexibacter woesei	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone D	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone D sulfate	-	Conexibacter woesei JCM 11494	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone D	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone D sulfate	-	Conexibacter woesei ID131577	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone D	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone D sulfate	-	Conexibacter woesei CIP 108061	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone D	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone D sulfate	-	Conexibacter woesei DSM 14684	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone D	-	?
(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine + conexipyrone D sulfate	-	Conexibacter woesei NBRC 100937	(5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-[[(2S)-2-hydroxytridecanoyl]oxy]-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]-2'-O-sulfouridine + conexipyrone D	-	?
additional information	conexipyrones isolated from Conexibacter woesei function as sulfate shuttles in a two-enzyme assay, because their sulfated derivatives are accepted as donor molecules by the PAPS-independent arylsulfate sulfotransferase (ASST) Cpz4 to yield sulfated caprazamycin intermediates. Conexipyrones are also the genuine sulfate acceptor substrates of PAPS-dependent sulfotransferase CwoeST	Conexibacter woesei	?	-	-
additional information	conexipyrones isolated from Conexibacter woesei function as sulfate shuttles in a two-enzyme assay, because their sulfated derivatives are accepted as donor molecules by the PAPS-independent arylsulfate sulfotransferase (ASST) Cpz4 to yield sulfated caprazamycin intermediates. Conexipyrones are also the genuine sulfate acceptor substrates of PAPS-dependent sulfotransferase CwoeST	Conexibacter woesei JCM 11494	?	-	-
additional information	conexipyrones isolated from Conexibacter woesei function as sulfate shuttles in a two-enzyme assay, because their sulfated derivatives are accepted as donor molecules by the PAPS-independent arylsulfate sulfotransferase (ASST) Cpz4 to yield sulfated caprazamycin intermediates. Conexipyrones are also the genuine sulfate acceptor substrates of PAPS-dependent sulfotransferase CwoeST	Conexibacter woesei ID131577	?	-	-
additional information	conexipyrones isolated from Conexibacter woesei function as sulfate shuttles in a two-enzyme assay, because their sulfated derivatives are accepted as donor molecules by the PAPS-independent arylsulfate sulfotransferase (ASST) Cpz4 to yield sulfated caprazamycin intermediates. Conexipyrones are also the genuine sulfate acceptor substrates of PAPS-dependent sulfotransferase CwoeST	Conexibacter woesei CIP 108061	?	-	-
additional information	conexipyrones isolated from Conexibacter woesei function as sulfate shuttles in a two-enzyme assay, because their sulfated derivatives are accepted as donor molecules by the PAPS-independent arylsulfate sulfotransferase (ASST) Cpz4 to yield sulfated caprazamycin intermediates. Conexipyrones are also the genuine sulfate acceptor substrates of PAPS-dependent sulfotransferase CwoeST	Conexibacter woesei DSM 14684	?	-	-
additional information	conexipyrones isolated from Conexibacter woesei function as sulfate shuttles in a two-enzyme assay, because their sulfated derivatives are accepted as donor molecules by the PAPS-independent arylsulfate sulfotransferase (ASST) Cpz4 to yield sulfated caprazamycin intermediates. Conexipyrones are also the genuine sulfate acceptor substrates of PAPS-dependent sulfotransferase CwoeST	Conexibacter woesei NBRC 100937	?	-	-

Synonyms

Synonyms	Comment	Organism
ASST	-	Conexibacter woesei
Cpz4	-	Conexibacter woesei
CwoeST	-	Conexibacter woesei
Cwoe_4788	locus name	Conexibacter woesei
PAPS-independent ASST	-	Conexibacter woesei
PAPS-independent sulfotransferase	-	Conexibacter woesei