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Literature summary for 2.8.2.21 extracted from

  • Narentuya, ; Takeda-Uchimura, Y.; Foyez, T.; Zhang, Z.; Akama, T.O.; Yagi, H.; Kato, K.; Komatsu, Y.; Kadomatsu, K.; Uchimura, K.
    GlcNAc6ST3 is a keratan sulfate sulfotransferase for the protein-tyrosine phosphatase PTPRZ in the adult brain (2019), Sci. Rep., 9, 4387 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.21

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + keratan Mus musculus pericellular localization of R-10G reactive KS epitopes in perineuronal net-positive neurons in the visual cortex of adult mice adenosine 3',5'-bisphosphate + keratan 6'-sulfate
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 ?
3'-phosphoadenylyl sulfate + keratan Mus musculus C57BL/6 J pericellular localization of R-10G reactive KS epitopes in perineuronal net-positive neurons in the visual cortex of adult mice adenosine 3',5'-bisphosphate + keratan 6'-sulfate
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Organism

Organism UniProt Comment Textmining
Mus musculus Q9QUP4
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Mus musculus C57BL/6 J Q9QUP4
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Source Tissue

Source Tissue Comment Organism Textmining
brain enzyme GlcNAc-6-sulfated KS is recognized by the R-10G anti-KS antibody, of which the minimum epitope structure is Galbeta1-4GlcNAc(6S)beta1-3Galbeta1-4GlcNAc(6S), and distributes diffusely in neuropils and presents densely in close proximity to the perineuronal region of the perineuronal net (PNN)-positive neurons in the adult visual cortex Mus musculus
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intestine
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 Mus musculus
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additional information immunohistochemic analysis of the enzyme in brain samples Mus musculus
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neuron
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 Mus musculus
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oligodendrocyte
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + keratan
-
 Mus musculus adenosine 3',5'-bisphosphate + keratan 6'-sulfate
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 ?
3'-phosphoadenylyl sulfate + keratan pericellular localization of R-10G reactive KS epitopes in perineuronal net-positive neurons in the visual cortex of adult mice Mus musculus adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
 ?
3'-phosphoadenylyl sulfate + keratan
-
 Mus musculus C57BL/6 J adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
 ?
3'-phosphoadenylyl sulfate + keratan pericellular localization of R-10G reactive KS epitopes in perineuronal net-positive neurons in the visual cortex of adult mice Mus musculus C57BL/6 J adenosine 3',5'-bisphosphate + keratan 6'-sulfate
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 ?

Synonyms

Synonyms Comment Organism
Chst5
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 Mus musculus
GlcNAc6ST3
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 Mus musculus
keratan sulfate sulfotransferase
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 Mus musculus

General Information

General Information Comment Organism
physiological function keratan sulfate (KS) is a carbohydrate side chain covalently attached to extracellular proteoglycans. KS is composed of disaccharide units of 6-sulfated N-acetylglucosamine (GlcNAc) and galactose. GlcNAc6ST3 is a major sulfotransferase for the R-10G-positive KS in the adult mouse brain. GlcNAc-6-O-sulfotransferase (GlcNAc6ST) 1 encoded by Chst5 is an enzyme necessary for the synthesis of GlcNAc-6-sulfated KS chains which are required for neuronal plasticity in the visual cortex of the mouse brain during the critical period, but not in adulthood. GlcNAc-6-sulfated KS is recognized by the R-10G anti-KS antibody, of which the minimum epitope structure is Galbeta1-4GlcNAc(6S)beta1-3Galbeta1-4GlcNAc(6S), and distributes diffusely in neuropils and presents densely in close proximity to the perineuronal region of the perineuronal net (PNN)-positive neurons in the adult visual cortex. GlcNAc6ST3, which has been discovered as an intestinal GlcNAc6ST encoded by Chst5, is a major brain KS sulfotransferase expressed in oligodendrocytes in adulthood. An isoform of the protein-tyrosine phosphatase PTPRZ is also a R-10G-reactive KS proteoglycan. GlcNAc6ST3 may play a role in synthesis of a component of PNN in the adult brain, and the KS-modified isoform of PTPRZ encoded by Ptprz1 might be an extracellular molecule associated with PNNs Mus musculus