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Literature summary for 2.8.2.21 extracted from

  • Tateno, H.; Ohnishi, K.; Yabe, R.; Hayatsu, N.; Sato, T.; Takeya, M.; Narimatsu, H.; Hirabayashi, J.
    Dual specificity of Langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain (2009), J. Biol. Chem., 285, 6390-6400.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.21

Cloned(Commentary)

Cloned (Comment) Organism
stable expression and co-expression of Langerin gene and keratan sulfate Gal-6-sulfotransferase gene CHST1 in CHO cells, expression of fluorescent tagged Langerin, quantitative real-time PCR analysis of the KS6ST in human tissue Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + keratan Homo sapiens
-
 adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 gene CHST1 encodes the keratan sulfate 6-O-sulfotransferase
-

Source Tissue

Source Tissue Comment Organism Textmining
brain high expression of sulfate 6-O-sulfotransferase Homo sapiens
-
commercial preparation
-
 Homo sapiens
-
LN-229 cell
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
additional information tissue expression analysis of Langerin and KS6ST Homo sapiens
-
pancreas
-
 Homo sapiens
-
spleen high expression of sulfate 6-O-sulfotransferase Homo sapiens
-
thyroid gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + keratan
-
 Homo sapiens adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
CHST1
-
 Homo sapiens
keratan sulfate 6-O-sulfotransferase
-
 Homo sapiens
keratan sulfate Gal-6-sulfotransferase
-
 Homo sapiens
KS6ST
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function KS6ST transfers sulfate to the C-6 of Gal of LacNAc on glycoproteins and is responsible for the generation of a Langerin ligands. Langerin plays roles in the first line defense against pathogens and in Birbeck granule formation in Langerhans cells, vLangerin is categorized as a C-type lectin. It recognizes pathogenic fungi, such as Candida sp. and Malassezia sp., expressing heavily mannosylated glycans, Langerin recognizes 6'-sulfo-LacNAc as a preferred, glycan ligand, overview Homo sapiens