Cloned (Comment) | Organism |
---|---|
isozyme TPST-2, expression analysis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of isozyme TPST-2 deficient growth-retarded mutant mice, phenotype, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | - |
Mus musculus | 5794 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + protein tyrosine | Mus musculus | - |
adenosine 3',5'-bisphosphate + protein tyrosine O-sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
wild-type DW/J mice and mutant grt mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
liver | high TPST-2 expression level | Mus musculus | - |
lung | low TPST-2 expression level | Mus musculus | - |
additional information | the expression of TPST2 protein in various tissues of wild-type DW/J mice | Mus musculus | - |
ovary | - |
Mus musculus | - |
testis | - |
Mus musculus | - |
thyroid gland | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + protein tyrosine | - |
Mus musculus | adenosine 3',5'-bisphosphate + protein tyrosine O-sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPST2 | - |
Mus musculus |
tyrosylprotein sulfotransferase-2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | deficiency in the enzymatic activity of isozyme TPST2 causes growth-retardation in mice, autosomal recessive hypothyroidism, and lifelong female infertility. The isozyme deficiency is also involved in severe thyroid hypogenesis and consequent dwarfism, due to the impairment of the tyrosine sulfation of thyroid-stimulating hormone receptor by mutant TPST2 | Mus musculus |