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Literature summary for 2.8.2.20 extracted from

  • Sasaki, N.; Hosoda, Y.; Nagata, A.; Ding, M.; Cheng, J.M.; Miyamoto, T.; Okano, S.; Asano, A.; Miyoshi, I.; Agui, T.
    A mutation in Tpst2 encoding tyrosylprotein sulfotransferase causes dwarfism associated with hypothyroidism (2007), Mol. Endocrinol., 21, 1713-1721.
    View publication on PubMed
Search for more literature for 2.8.2.20

Cloned(Commentary)

Cloned (Comment) Organism
gene Tpst2, wild-type and mutant enzymes genotyping and genetic mapping, expression of genes Tpst1 and Tpst2 in grt mouse cells, rescue of the phenotype, overview Mus musculus

Protein Variants

Protein Variants Comment Organism
H266Q missense mutation of Tpst2, devoid of activity, in the highly conserved region of the gene leads to the autosomal recessive, fetal-onset, severe thyroid hypoplasia phenotype related to TSH hyporesponsiveness in growth-retarded mice, the mutant enzyme shows unaltered subcellular localization, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + protein tyrosine Mus musculus tyrosine sulfonation of TSHR by TPST is crucial for thyrotropin signaling, overview adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
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 ?
3'-phosphoadenylyl sulfate + TSH receptor Mus musculus tyrosine sulfonation of TSHR by TPST2 is crucial for thyrotropin signaling, TPST1 and TPST2 mutant H266Q are incapable of mediating the signal transduction, overview adenosine 3',5'-bisphosphate + TSH receptor O-sulfate
-
 ?
additional information Mus musculus missense mutation of Tpst2 leads to the autosomal recessive, fetal-onset, severe thyroid hypoplasia phenotype related to TSH hyporesponsiveness in growth-retarded mice, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 C57BL/6J and grt mice, two isozymes encoded by genes Tpst1 and Tpst2
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast primary Mus musculus
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additional information isozyme genes Tpst1 and Tpst2 tissue expression analysis Mus musculus
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NIH-3T3 cell
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 Mus musculus
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thyrocyte
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 Mus musculus
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thyroid gland
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + protein tyrosine
-
 Mus musculus adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
 ?
3'-phosphoadenylyl sulfate + protein tyrosine tyrosine sulfonation of TSHR by TPST is crucial for thyrotropin signaling, overview Mus musculus adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
 ?
3'-phosphoadenylyl sulfate + TSH receptor
-
 Mus musculus adenosine 3',5'-bisphosphate + TSH receptor O-sulfate
-
 ?
3'-phosphoadenylyl sulfate + TSH receptor tyrosine sulfonation of TSHR by TPST2 is crucial for thyrotropin signaling, TPST1 and TPST2 mutant H266Q are incapable of mediating the signal transduction, overview Mus musculus adenosine 3',5'-bisphosphate + TSH receptor O-sulfate
-
 ?
additional information missense mutation of Tpst2 leads to the autosomal recessive, fetal-onset, severe thyroid hypoplasia phenotype related to TSH hyporesponsiveness in growth-retarded mice, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
TPST
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 Mus musculus
tyrosylprotein sulfotransferase
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 Mus musculus