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Literature summary for 2.8.2.2 extracted from

  • Yip, C.K.Y.; Bansal, S.; Wong, S.Y.; Lau, A.J.
    Identification of galeterone and abiraterone as inhibitors of dehydroepiandrosterone sulfonation catalyzed by human hepatic cytosol, SULT2A1, SULT2B1b, and SULT1E1 (2018), Drug Metab. Dispos., 46, 470-482 .
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
abiraterone antiandrogen drug, metabolite abiraterone, not the parent drug abiraterone acetate, is responsible for the inhibition; antiandrogen drug, metabolite abiraterone, not the parent drug abiraterone acetate, is responsible for the inhibition Homo sapiens
cyproterone acetate
-
 Homo sapiens
danazol
-
 Homo sapiens
galeterone antiandrogen drug; antiandrogen drug Homo sapiens
spironolactone
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O00204 isoform SULT2B1
-
Homo sapiens Q06520 isoform SULT2A1
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?

Synonyms

Synonyms Comment Organism
SULT2A1
-
 Homo sapiens
SULT2B1
-
 Homo sapiens