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Literature summary for 2.8.2.2 extracted from

  • Uno, Y.; Murayama, N.; Yamazaki, H.
    Molecular and functional characterization of cytosolic sulfotransferases in cynomolgus macaque (2019), Biochem. Pharmacol., 166, 153-162 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene SULT1A1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, gene structure and genomic organization of each cynomolgus SULTs, SULT1A1 and SULT1A3 form a gene cluster with SULT1A1-like and SULT1A-like genes on chromosome 20, recombinant expression in Escherichia coli cytosol, quantitative real-time RT-PCR enzyme expression analysis Macaca fascicularis
gene SULT1A1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, gene structure and genomic organization of each cynomolgus SULTs, SULT1B1 and SULT1E1 form a gene cluster, recombinant expression in Escherichia coli cytosol, quantitative real-time RT-PCR enzyme expression analysis Macaca fascicularis
gene SULT1A1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, gene structure and genomic organization of each cynomolgus SULTs, SULT1B1 and SULT1E1 formed a gene cluster, recombinant expression in Escherichia coli cytosol, quantitative real-time RT-PCR enzyme expression analysis Macaca fascicularis
gene SULT1A1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, gene structure and genomic organization of each cynomolgus SULTs, SULT1C2v1, SULT1C2v2, and SULT1C4 form a gene cluster with a SULT1C3-like gene, recombinant expression in Escherichia coli cytosol, quantitative real-time RT-PCR enzyme expression analysis Macaca fascicularis
gene SULT1A1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, gene structure and genomic organization of each cynomolgus SULTs, SULT2A1 is located on chromosome 19 where also a SULT2B1-like gene is located, recombinant expression in Escherichia coli cytosol, quantitative real-time RT-PCR enzyme expression analysis Macaca fascicularis

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Macaca fascicularis 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + 1-naphthol Macaca fascicularis
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone Macaca fascicularis
-
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
?
3'-phosphoadenylyl sulfate + dopamine Macaca fascicularis
-
adenosine 3',5'-bisphosphate + dopamine sulfate
-
?

Organism

Organism UniProt Comment Textmining
Macaca fascicularis
-
-
-
Macaca fascicularis A0A2K5UIK9
-
-
Macaca fascicularis A0A2K5VZW5
-
-
Macaca fascicularis A0A2K5X3B6
-
-
Macaca fascicularis P52842
-
-
Macaca fascicularis Q2XV97
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Macaca fascicularis
-
brain
-
Macaca fascicularis
-
brain very low level Macaca fascicularis
-
heart
-
Macaca fascicularis
-
heart low level Macaca fascicularis
-
jejunum predominantly Macaca fascicularis
-
jejunum very low level Macaca fascicularis
-
jejunum high level Macaca fascicularis
-
jejunum moderate level Macaca fascicularis
-
kidney
-
Macaca fascicularis
-
kidney predominantly Macaca fascicularis
-
kidney high level Macaca fascicularis
-
liver
-
Macaca fascicularis
-
liver predominantly Macaca fascicularis
-
liver predominately Macaca fascicularis
-
lung
-
Macaca fascicularis
-
additional information quantitative real-time RT-PCR enzyme expression analysis in female and male tissue samples, tissue distribution and expression pattern, overview Macaca fascicularis
-
additional information quantitative real-time RT-PCR enzyme expression analysis in female and male tissue samples, tissue distribution and expression pattern, overview. SULT1A3 is expressed in all the tissues, but most predominantly in jejunum, followed by liver Macaca fascicularis
-
ovary
-
Macaca fascicularis
-
small intestine
-
Macaca fascicularis
-
testis
-
Macaca fascicularis
-
testis low level Macaca fascicularis
-
testis moderate to low level Macaca fascicularis
-
uterus
-
Macaca fascicularis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 1-naphthol
-
Macaca fascicularis adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
3'-phosphoadenylyl sulfate + 1-naphthol best substrate Macaca fascicularis adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
3'-phosphoadenylyl sulfate + 1-naphthol high activity Macaca fascicularis adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
-
Macaca fascicularis adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol best substrate Macaca fascicularis adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
Macaca fascicularis adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol best substrate Macaca fascicularis adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
Macaca fascicularis adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone best substrate Macaca fascicularis adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
?
3'-phosphoadenylyl sulfate + dopamine
-
Macaca fascicularis adenosine 3',5'-bisphosphate + dopamine sulfate
-
?

Synonyms

Synonyms Comment Organism
cytosolic sulfotransferase
-
Macaca fascicularis
More cf. EC 2.8.2.4 Macaca fascicularis
SULT1A3
-
Macaca fascicularis
SULT1B1
-
Macaca fascicularis
SULT1C2
-
Macaca fascicularis
SULT1C2v1
-
Macaca fascicularis
SULT1C2v2
-
Macaca fascicularis
SULT1C4
-
Macaca fascicularis
SULT2A1
-
Macaca fascicularis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Macaca fascicularis

General Information

General Information Comment Organism
evolution gene structure and genomic organization of each cynomolgus SULTs are similar to those of the human orthologues. SULT1A3 and SULT1A4 have arisen from the single gene by gene duplication and encode the same protein. Tissue distribution and sbstrate specificities of SULTS from humans and Cynomolgus macaques, overview Macaca fascicularis
evolution gene structure and genomic organization of each cynomolgus SULTs are similar to those of the human orthologues. SULT1B1 and SULT1E1 form a gene cluster Macaca fascicularis
evolution gene structure and genomic organization of each cynomolgus SULTs are similar to those of the human orthologues. SULT1B1 and SULT1E1 formed a gene cluster. Tissue distribution and sbstrate specificities of SULTS from humans and Cynomolgus macaques, overview Macaca fascicularis
evolution gene structure and genomic organization of each cynomolgus SULTs are similar to those of the human orthologues. SULT1C2v1, SULT1C2v2, and SULT1C4 form a gene cluster with a SULT1C3-like gene. Tissue distribution and sbstrate specificities of SULTS from humans and Cynomolgus macaques, overview Macaca fascicularis
evolution gene structure and genomic organization of each cynomolgus SULTs are similar to those of the human orthologues. The cynomolgus SULT1C2v2 is highly homologous to human SULT1C2P1 (pseudogene). Tissue distribution and sbstrate specificities of SULTS from humans and Cynomolgus macaques, overview Macaca fascicularis
evolution gene structure and genomic organization of each cynomolgus SULTs are similar to those of the human orthologues. Tissue distribution and sbstrate specificities of SULTS from humans and Cynomolgus macaques, overview Macaca fascicularis