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Literature summary for 2.8.2.2 extracted from

  • Shi, X.; Cheng, Q.; Xu, L.; Yan, J.; Jiang, M.; He, J.; Xu, M.; Stefanovic-Racic, M.; Sipula, I.; ODoherty, R.M.; Ren, S.; Xie, W.
    Cholesterol sulfate and cholesterol sulfotransferase inhibit gluconeogenesis by targeting hepatocyte nuclear factor 4? (2014), Mol. Cell. Biol., 34, 485-497.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.2

Organism

Organism UniProt Comment Textmining
Mus musculus O35400
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-

Source Tissue

Source Tissue Comment Organism Textmining
Hepa1-6 cell
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 Mus musculus
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liver
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + cholesterol
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 Mus musculus adenosine 3',5'-bisphosphate + cholesterol sulfate
-
 ?

Synonyms

Synonyms Comment Organism
cholesterol sulfotransferase
-
 Mus musculus
SULT2B1b
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus the expression of SULT2B1b in the liver is induced in obese mice and during the transition from the fasted to the fed state up

General Information

General Information Comment Organism
metabolism isoform SULT2B1b and its enzymatic by-product cholesterol sulfate are important metabolic regulators that control glucose metabolism. Mechanistically, cholesterol sulfate and SULT2B1b inhibit gluconeogenesis by suppressing the expression of acetyl coenzyme A synthetase, leading to decreased acetylation and nuclear exclusion of hepatocyte nuclear factor 4alpha. Mus musculus