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Literature summary for 2.8.2.2 extracted from

  • Ekuase, E.J.; Lehmler, H.J.; Robertson, L.W.; Duffel, M.W.
    Binding interactions of hydroxylated polychlorinated biphenyls (OHPCBs) with human hydroxysteroid sulfotransferase hSULT2A1 (2014), Chem. Biol. Interact., 212, 56-64.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.2

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3,3',4'-dihydroxy-4-monochlorobiphenyl
-
 Homo sapiens
4'-hydroxy-2',3,4-trichlorobiphenyl
-
 Homo sapiens
4'-hydroxy-2,3',4,5'-tetrachlorobiphenyl
-
 Homo sapiens
4'-hydroxy-2,3',4-trichlorobiphenyl
-
 Homo sapiens
4'-hydroxy-2,3'-dichlorobiphenyl
-
 Homo sapiens
4'-hydroxy-2,5-dichlorobiphenyl
-
 Homo sapiens
4'-hydroxy-3,4-dichlorobiphenyl
-
 Homo sapiens
4'-hydroxy-4-monochlorobiphenyl
-
 Homo sapiens
4-hydroxy-2',3,5-trichlorobiphenyl
-
 Homo sapiens
4-hydroxy-2,4'-dichlorobiphenyl
-
 Homo sapiens
4-hydroxy-3,3',5-trichlorobiphenyl
-
 Homo sapiens
4-hydroxy-3,3'-dichlorobiphenyl
-
 Homo sapiens
4-hydroxy-3,5-dichlorobiphenyl
-
 Homo sapiens
5,3',4'-dihydroxy-2,3-dichlorobiphenyl
-
 Homo sapiens
6'-hydroxy-3,3'4-trichlorobiphenyl
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q06520
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
hydroxysteroid sulfotransferase
-
 Homo sapiens
SULT2A1
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0006
-
 4'-hydroxy-2,3',4,5'-tetrachlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.0007
-
 4'-hydroxy-2,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.0008
-
 4-hydroxy-2',3,5-trichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.003
-
 4'-hydroxy-2',3,4-trichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.003
-
 4'-hydroxy-2,3',4-trichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.0034
-
 4-hydroxy-3,3',5-trichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.004
-
 4'-hydroxy-3,4-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.005
-
 4-hydroxy-2,4'-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.0054
-
 4'-hydroxy-2,3'-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.009
-
 6'-hydroxy-3,3'4-trichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.012
-
 4-hydroxy-3,3'-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.0135
-
 4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.014
-
 5,3',4'-dihydroxy-2,3-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.017
-
 4'-hydroxy-4-monochlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.032
-
 3,3',4'-dihydroxy-4-monochlorobiphenyl at pH 7.0 and 37°C Homo sapiens