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Literature summary for 2.8.2.2 extracted from

  • Yang, X.; Xu, Y.; Guo, F.; Ning, Y.; Zhi, X.; Yin, L.; Li, X.
    Hydroxysteroid sulfotransferase SULT2B1b promotes hepatocellular carcinoma cells proliferation in vitro and in vivo (2013), PLoS ONE, 8, e60853.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in the mouse hepatocarcinoma cell line Hepa1-6 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O00204
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BEL-7402 cell
-
Homo sapiens
-
HEP-3B cell
-
Homo sapiens
-
hepatocellular carcinoma cell
-
Homo sapiens
-
Huh-7 cell
-
Homo sapiens
-
SMMC-7721 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + cholesterol
-
Homo sapiens adenosine 3',5'-bisphosphate + cholesterol sulfate
-
?

Synonyms

Synonyms Comment Organism
hydroxysteroid sulfotransferase
-
Homo sapiens
SULT2B1b
-
Homo sapiens

General Information

General Information Comment Organism
malfunction knock-down of SULT2B1b inhibits cell growth and cyclinB1 levels in human hepatocarcinoma cells and suppressed xenograft growth in vivo Homo sapiens
physiological function SULT2B1b expression promotes proliferation of hepatocellular carcinoma cells in vitro and in vivo, which may contribute to the progression of hepatocellular carcinoma Homo sapiens