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Literature summary for 2.8.2.2 extracted from

  • Khor, V.K.; Tong, M.H.; Qian, Y.; Song, W.C.
    Gender-specific expression and mechanism of regulation of estrogen sulfotransferase in adipose tissues of the mouse (2008), Endocrinology, 149, 5440-5448.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information liver X receptor antagonist TO-901317 induces estrogen sulfotransferase expression in female liver, but not in the adipose tissue Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information male estrogen sulfotransferase-knockout mice develop increased epididymal fat accumulation with enlarged adipocyte size, phenotype, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + estradiol Mus musculus estrogen sulfotransferase expression in adipose tissue is regulated by testosterone, overview adenosine 3',5'-bisphosphate + estradiol sulfate
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue male white epididymal fat pad, no expression in brown fat Mus musculus
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liver
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Mus musculus
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additional information no estrogen sulfotransferase expression in brown adipose tissue, differential expression of estrogen sulfotransferase in fat and liver, overview Mus musculus
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white adipose tissue of male, but not of female mice. Testosterone-dependent, gender-specific expression of estrogen sulfotransferase in adipose tissue Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + estradiol
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Mus musculus adenosine 3',5'-bisphosphate + estradiol sulfate
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?
3'-phosphoadenylyl sulfate + estradiol estrogen sulfotransferase expression in adipose tissue is regulated by testosterone, overview Mus musculus adenosine 3',5'-bisphosphate + estradiol sulfate
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?

Synonyms

Synonyms Comment Organism
estrogen sulfotransferase
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Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus