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Literature summary for 2.8.2.2 extracted from

  • Apak, T.I.; Duffel, M.W.
    Interactions of the stereoisomers of alpha-hydroxytamoxifen with human hydroxysteroid sulfotransferase SULT2A1 and rat hydroxysteroid sulfotransferase STa (2004), Drug Metab. Dispos., 32, 1501-1508.
    View publication on PubMed
Search for more literature for 2.8.2.2

Inhibitors

Inhibitors Comment Organism Structure
E-(-)-alpha-hydroxytamoxifen inhibits sulfation of E-(+)-alpha-hydroxytamoxifen Rattus norvegicus
Z-(+)-alpha-hydroxytamoxifen inhibits sulfation of E-(+)-alpha-hydroxytamoxifen Rattus norvegicus
Z-(-)-alpha-hydroxytamoxifen inhibits sulfation of E-(+)-alpha-hydroxytamoxifen Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0358
-
 E-(-)-alpha-hydroxytamoxifen pH 8.0, 37°C Homo sapiens
0.0405
-
 Z-(-)-alpha-hydroxytamoxifen pH 8.0, 37°C Homo sapiens
0.0465
-
 E-(+)-alpha-hydroxytamoxifen pH 8.0, 37°C Homo sapiens
0.0669
-
 Z-(+)-alpha-hydroxytamoxifen pH 8.0, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + alpha-hydroxytamoxifen all enantiomers are substrates: E-(+)-alpha-hydroxytamoxifen, E-(-)-alpha-hydroxytamoxifen, Z-(+)-alpha-hydroxytamoxifen and Z-(-)-alpha-hydroxytamoxifen. The ratio of turnover-number to KM-value is higher with the Z enantiomers than with the E enantiomers Homo sapiens adenosine 3',5'-bisphosphate + sulfuric acid mono-[(E)-4-[4-(2-dimethylaminoethoxy)-phenyl]-3,4-diphenylbut-3-enyl] ester
-
 ?
3'-phosphoadenylylsulfate + E-(+)-alpha-hydroxytamoxifen
-
 Homo sapiens adenosine 3',5'-bisphosphate + sulfuric acid mono-[(E)-4-[4-(2-dimethylaminoethoxy)-phenyl]-3,4-diphenylbut-3-enyl] ester
-
 ?
3'-phosphoadenylylsulfate + E-(+)-alpha-hydroxytamoxifen E-(+)-alpha-hydroxytamoxifen is the only substrate, E-(-)-alpha-hydroxytamoxifen, Z-(+)-alpha-hydroxytamoxifen and Z-(-)-alpha-hydroxytamoxifen inhibit sulfation of E-(+)-alpha-hydroxytamoxifen Rattus norvegicus adenosine 3',5'-bisphosphate + sulfuric acid mono-[(E)-4-[4-(2-dimethylaminoethoxy)-phenyl]-3,4-diphenylbut-3-enyl] ester
-
 ?
3'-phosphoadenylylsulfate + E-(-)-alpha-hydroxytamoxifen
-
 Homo sapiens adenosine 3',5'-bisphosphate + sulfuric acid mono-[(E)-4-[4-(2-dimethylaminoethoxy)-phenyl]-3,4-diphenylbut-3-enyl] ester
-
 ?
3'-phosphoadenylylsulfate + Z-(+)-alpha-hydroxytamoxifen
-
 Homo sapiens adenosine 3',5'-bisphosphate + sulfuric acid mono-[(Z)-4-[4-(2-dimethylaminoethoxy)-phenyl]-3,4-diphenylbut-3-enyl] ester
-
 ?
3'-phosphoadenylylsulfate + Z-(-)-alpha-hydroxytamoxifen
-
 Homo sapiens adenosine 3',5'-bisphosphate + sulfuric acid mono-[(Z)-4-[4-(2-dimethylaminoethoxy)-phenyl]-3,4-diphenylbut-3-enyl] ester
-
 ?

Synonyms

Synonyms Comment Organism
hydroxysteroid sulfotransferase Sta
-
 Rattus norvegicus
hydroxysteroid sulfotransferase SULT2A1
-
 Homo sapiens
STA
-
 Rattus norvegicus
SULT2A1
-
 Homo sapiens