Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.8.2.2 extracted from

  • Kudlacek, P.E.; Clemens, D.L.; Halgard, C.M.; Anderson, R.J.
    Characterization of recombinant human liver dehydroepiandrosterone sulfotransferase with minoxidil as the substrate (1997), Biochem. Pharmacol., 53, 215-221.
    View publication on PubMed
Search for more literature for 2.8.2.2

Activating Compound

Activating Compound Comment Organism Structure
NaCl leads to a greater activation of the cDNA-expressed DHEA ST when assayed with dehydroepiandrosterone Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
DHEA ST cloned from cDNA and expressed in COS-1 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,6-Dichloro-4-nitrophenol
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00013
-
 3'-phosphoadenylylsulfate pH 7.5, 37°C Homo sapiens
3.9
-
 minoxidil pH 7.5, 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylylsulfate + dehydroepiandrosterone Homo sapiens biotransformation of xenobiotics and hormones through sulfate conjugation, important metabolic pathway adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 r
3'-phosphoadenylylsulfate + dehydroepiandrosterone biotransformation of xenobiotics and hormones through sulfate conjugation, important metabolic pathway Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 r
3'-phosphoadenylylsulfate + minoxidil antihypertensive agent and hair growth stimulator, activation by sulfation Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?

Synonyms

Synonyms Comment Organism
DHEA ST
-
 Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4 43 50% inactivation temperature for COS-expressed enzyme 42°C Homo sapiens