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Literature summary for 2.8.2.18 extracted from
- Glucocorticoid sulphotransferases in rats and other animal species (1984), Biochem. Soc. Trans., 12, 35-39.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Antibodies to sulfotransferase III | sulfotransferase I | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.007 | - |
cortisol | pH 6.8, sulfotransferase I and III | Rattus norvegicus |  |
| 0.007 | - |
3'-phosphoadenylylsulfate | pH 6.8, sulfotransferase III | Rattus norvegicus | |
| 0.007 | 0.02 | cortisol | - |
Gallus gallus | |
| 0.007 | 0.02 | cortisol | - |
Bos taurus | |
| 0.011 | - |
3'-phosphoadenylylsulfate | pH 6.8, sulfotransferase I | Rattus norvegicus | |
| 0.15 | 0.188 | 3'-phosphoadenylylsulfate | - |
Cavia porcellus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Gallus gallus | 5829 | - |
| cytosol | - |
Cavia porcellus | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Bos taurus | 5829 | - |
| cytosol | - |
Mesocricetus auratus | 5829 | - |
| cytosol | - |
Meriones sp. | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 28000 | - |
6 * 28000, sulfotransferase I, SDS-PAGE | Rattus norvegicus |
| 30000 | - |
2 * 30000, sulfotransferase III, SDS-PAGE | Rattus norvegicus |
| 160000 | - |
sulfotransferase I | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylylsulfate + cortisol | Gallus gallus | - |
adenosine 3',5'-bisphosphate + cortisol 21-sulfate | - |
? | |
| 3'-phosphoadenylylsulfate + cortisol | Cavia porcellus | - |
adenosine 3',5'-bisphosphate + cortisol 21-sulfate | - |
? | |
| 3'-phosphoadenylylsulfate + cortisol | Rattus norvegicus | - |
adenosine 3',5'-bisphosphate + cortisol 21-sulfate | - |
? | |
| 3'-phosphoadenylylsulfate + cortisol | Bos taurus | - |
adenosine 3',5'-bisphosphate + cortisol 21-sulfate | - |
? | |
| 3'-phosphoadenylylsulfate + cortisol | Mesocricetus auratus | - |
adenosine 3',5'-bisphosphate + cortisol 21-sulfate | - |
? | |
| 3'-phosphoadenylylsulfate + cortisol | Meriones sp. | - |
adenosine 3',5'-bisphosphate + cortisol 21-sulfate | - |
? | |
| additional information | Rattus norvegicus | involved in control of corticosteroid metabolism | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cavia porcellus | - |
- |
- |
| Gallus gallus | - |
- |
- |
| Meriones sp. | - |
- |
- |
| Mesocricetus auratus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| sulfotransferase I | Rattus norvegicus |
| the use of frozen liver or cytosol stored on ice for more than 1-2 h reduces the yield of sulfotransferase I greatly | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Gallus gallus | - |
| liver | - |
Cavia porcellus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| liver | - |
Mesocricetus auratus | - |
| liver | - |
Meriones sp. | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylylsulfate + cortisol | - |
Gallus gallus | adenosine 3',5'-bisphosphate + cortisol 21-sulfate | - |
? | |
| 3'-phosphoadenylylsulfate + cortisol | - |
Cavia porcellus | adenosine 3',5'-bisphosphate + cortisol 21-sulfate | - |
? | |
| 3'-phosphoadenylylsulfate + cortisol | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + cortisol 21-sulfate | - |
? | |
| 3'-phosphoadenylylsulfate + cortisol | - |
Bos taurus | adenosine 3',5'-bisphosphate + cortisol 21-sulfate | - |
? | |
| 3'-phosphoadenylylsulfate + cortisol | - |
Mesocricetus auratus | adenosine 3',5'-bisphosphate + cortisol 21-sulfate | - |
? | |
| 3'-phosphoadenylylsulfate + cortisol | - |
Meriones sp. | adenosine 3',5'-bisphosphate + cortisol 21-sulfate | - |
? | |
| additional information | involved in control of corticosteroid metabolism | Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 30000, sulfotransferase III, SDS-PAGE | Rattus norvegicus |
| hexamer | 6 * 28000, sulfotransferase I, SDS-PAGE | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
pI: 6.5 | Gallus gallus |
| additional information | - |
pI: 6.5 | Rattus norvegicus |
| additional information | - |
pI: 6.5 | Bos taurus |
| additional information | - |
pI: 6.5 | Mesocricetus auratus |
| additional information | - |
pI: 6.5 | Meriones sp. |
| 6 | - |
cortisol as substrate | Rattus norvegicus |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Rattus norvegicus | - |
- |
6.5 |
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