Literature summary for 2.8.2.17 extracted from

Sawada, T.; Fujii, S.; Nakano, H.; Ohtake, S.; Kimata, K.; Habuchi, O.
Synthesis of sulfated phenyl 2-acetamido-2-deoxy-D-galactopyranosides. 4-O-Sulfated phenyl 2-acetamido-2-deoxy-beta-D-galactopyranoside is a competitive acceptor that decreases sulfation of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (2005), Carbohydr. Res., 340, 1983-1996.

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Inhibitors

Inhibitors	Comment	Organism	Structure
phenyl 2-acetamido-2-deoxy-4-O-sulfonato-D-galactopyranose	competitive, 5 mM, 76% inhibition, specific	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.038	-	chondroitin 4-sulfate	pH 6.8, 37°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant enzyme with FLAG-tag	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3'-phosphoadenylylsulfate + chondroitin 4-sulfate	-	Homo sapiens	adenosine 3',5'-bisphosphate + chondroitin 4,6-bissulfate	-	?
3'-phosphoadenylylsulfate + phenyl 2-acetamido-2-deoxy-4-O-sulfonato-D-galactopyranose	-	Homo sapiens	adenosine 3',5'-bisphosphate + phenyl 2-acetamido-2-deoxy-4,6-di-O-sulfonato-D-galactopyranose	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.98	-	phenyl 2-acetamido-2-deoxy-4-O-sulfonato-D-galactopyranose	pH 6.8, 37°C	Homo sapiens

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Release 2023.1 (January 2023)