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Literature summary for 2.8.2.15 extracted from

  • Yang, X.; Xu, Y.; Guo, F.; Ning, Y.; Zhi, X.; Yin, L.; Li, X.
    Hydroxysteroid sulfotransferase SULT2B1b promotes hepatocellular carcinoma cells proliferation in vitro and in vivo (2013), PLoS ONE, 8, e60853.
    View publication on PubMedView publication on EuropePMC
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41000
-
 x * 41000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylylsulfate + cholesterol Homo sapiens
-
 adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BEL-7402 cell
-
 Homo sapiens
-
HEP-3B cell
-
 Homo sapiens
-
HEPA 1-6 cell
-
 Homo sapiens
-
hepatocarcinoma cell
-
 Homo sapiens
-
Huh-7 cell
-
 Homo sapiens
-
SMMC-7721 cell highest expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + cholesterol
-
 Homo sapiens adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
-
 ?

Subunits

Subunits Comment Organism
? x * 41000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
hydroxysteroid sulfotransferase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens inhibition of SULT2B1b expression induces cell-cycle arrest and apoptosis in Hepa1-6 cells by upregulating the expression of FAS, downregulating the expression of cyclinB1, BCL2 and MYC in vitro and in vivo at both the transcript and protein levels. Knock-down of SULT2B1b expression significantly suppresses tumor growth in nude mouse xenografts down
Homo sapiens SULT2B1 is comparatively higher in the human hepatocarcinoma tumorous tissues than their adjacent tissues up

General Information

General Information Comment Organism
malfunction knockdown of SULT2B1 in Hepa1-6 cells induces cell-cycle arrest and apoptosis and suppresses tumorigenesis in vivo Homo sapiens
physiological function SULT2B1b expression promotes proliferation of hepatocellular carcinoma cells in vitro and in vivo, which may contribute to the progression of hepatocellular carcinoma Homo sapiens