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Literature summary for 2.8.2.15 extracted from

  • Echchgadda, I.; Song, C.S.; Oh, T.; Ahmed, M.; De La Cruz, I.J.; Chatterjee, B.
    The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase (2007), Mol. Endocrinol., 21, 2099-2111.
    View publication on PubMed
Search for more literature for 2.8.2.15

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme promoter contains composite elements inducible by nuclear receptors pregnane X receptor and constitutive androstane receptor, synergizing effects by HNF4alpha binding at a site near the promoter, overview Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene SULT2A1, expression and regulation analysis, the enzyme promoter contains composite elements inducible by nuclear receptors pregnane X receptor, PXR, and constitutive androstane receptor, CAR, synergizing effects by HNF4alpha binding at a site near the promoter, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information disruption of the DR4-type motif and the IR2-type motif prevents in vitro binding of nuclear receptors pregnane X receptor and constitutive androstane receptor to their specific binding sites, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme promotes phase II metabolism through its sulfonating action on certain endobiotics, including steroids and bile acids, and on diverse xenobiotics, including therapeutics drugs, regulation of enzyme expression involving HNF4alpha, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
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 Homo sapiens
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Hep-G2 cell
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 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme promotes phase II metabolism through its sulfonating action on certain endobiotics, including steroids and bile acids, and on diverse xenobiotics, including therapeutics drugs, regulation of enzyme expression involving HNF4alpha, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
steroid-/bile acid-sulfotransferase
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 Homo sapiens
SULT2A1
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 Homo sapiens