Literature summary for 2.8.2.15 extracted from

Seo, Y.K.; Chung, Y.T.; Kim, S.; Echchgadda, I.; Song, C.S.; Chatterjee, B.
Xenobiotic- and vitamin D-responsive induction of the steroid/bile acid-sulfotransferase Sult2A1 in young and old mice: the role of a gene enhancer in the liver chromatin (2007), Gene, 386, 218-223.

Search for more literature for 2.8.2.15

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	induction of SULT2A1 expression by xenobiotic-activated nuclear receptors pregnane X receptor PXR, constitutive androstane receptor CAR, and the vitamin D3-activated nuclear receptor VDR, aging has no effect on the activity of an IR0 enhancer in the Sult2A1 chromatin to recruit VDR, RXR-alpha, and PXR in mice injected with D3 or PCN	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
expression analysis of SULT2A1, induction of SULT2A1 expression by xenobiotic-activated nuclear receptors pregnane X receptor PXR, constitutive androstane receptor CAR, and the vitamin D3-activated nuclear receptor VDR, aging has no effect on the activity of an IR0 enhancer in the Sult2A1 chromatin to recruit VDR, RXR-alpha, and PXR in mice injected with D3 or PCN	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Mus musculus	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	Sult2A1 converts bile acids, steroids and a number of drugs to the corresponding sulfated metabolites, which are readily eliminated from the body due to increased water solubility, deviant expression of steroid- and xenobiotic-metabolizing enzymes due to metabolic stress causes severe health problems including accelerated aging, and increased expression of these enzymes is associated with extended longevity, overview, xenobiotic-activated nuclear receptors pregnane X receptor PXR, constitutive androstane receptor CAR, and the vitamin D3-activated nuclear receptor VDR regulating steroid and xenobiotic metabolism by inducing the phase I cytochrome P450 monooxygenases, phase II conjugating transferases, and the phase III transporters, are involved in enzyme regulation, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	of 4-month- and 20-month-old mice, SULT2A1 expression analysis, overview	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	Sult2A1 converts bile acids, steroids and a number of drugs to the corresponding sulfated metabolites, which are readily eliminated from the body due to increased water solubility, deviant expression of steroid- and xenobiotic-metabolizing enzymes due to metabolic stress causes severe health problems including accelerated aging, and increased expression of these enzymes is associated with extended longevity, overview, xenobiotic-activated nuclear receptors pregnane X receptor PXR, constitutive androstane receptor CAR, and the vitamin D3-activated nuclear receptor VDR regulating steroid and xenobiotic metabolism by inducing the phase I cytochrome P450 monooxygenases, phase II conjugating transferases, and the phase III transporters, are involved in enzyme regulation, overview	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
steroid/bile acid-sulfotransferase	-	Mus musculus
SULT2A1	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)