BRENDA - Enzyme Database show
show all sequences of 2.8.2.15

Non-genomic effects of endocrine disrupters: inhibition of estrogen sulfotransferase by phenols and chlorinated phenols

Harris, R.M.; Kirk, C.J.; Waring, R.H.; Mol. Cell. Endocrinol. 244, 72-74 (2005)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
2,3-dichlorophenol
IC50: 0.0007 mM, vs. 10 nM estradiol
Homo sapiens
2,4-Dichlorophenol
IC50: 0.0007 mM, vs. 10 nM estradiol
Homo sapiens
2,5-dichlorophenol
IC50: 0.0022 mM, vs. 10 nM estradiol
Homo sapiens
2,6-dichlorophenol
IC50: 0.0016 mM, vs. 10 nM estradiol
Homo sapiens
2-chlorophenol
IC50: 0.02 mM, vs. 10 nM estradiol
Homo sapiens
2-phenylphenol
IC50: 0.0052 mM, vs. 10 nM estradiol
Homo sapiens
3,4-dichlorophenol
IC50: 0.013 mM, vs. 10 nM estradiol
Homo sapiens
3,5-dichlorophenol
IC50: 0.017 mM, vs. 10 nM estradiol
Homo sapiens
3-chlorophenol
IC50: 0.13 mM, vs. 10 nM estradiol
Homo sapiens
4-chloro-3-methylphenol
IC50: 0.024 mM, vs. 10 nM estradiol
Homo sapiens
4-Chlorophenol
IC50: 0.11 mM, vs. 10 nM estradiol
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3'-phosphoadenylylsulfate + estradiol
-
662863
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0007
-
IC50: 0.0007 mM, vs. 10 nM estradiol
Homo sapiens
2,3-dichlorophenol
0.0007
-
IC50: 0.0007 mM, vs. 10 nM estradiol
Homo sapiens
2,4-Dichlorophenol
0.0016
-
IC50: 0.0016 mM, vs. 10 nM estradiol
Homo sapiens
2,6-dichlorophenol
0.0022
-
IC50: 0.0022 mM, vs. 10 nM estradiol
Homo sapiens
2,5-dichlorophenol
0.0052
-
IC50: 0.0052 mM, vs. 10 nM estradiol
Homo sapiens
2-phenylphenol
0.013
-
IC50: 0.013 mM, vs. 10 nM estradiol
Homo sapiens
3,4-dichlorophenol
0.017
-
IC50: 0.017 mM, vs. 10 nM estradiol
Homo sapiens
3,5-dichlorophenol
0.02
-
IC50: 0.02 mM, vs. 10 nM estradiol
Homo sapiens
2-chlorophenol
0.024
-
IC50: 0.024 mM, vs. 10 nM estradiol
Homo sapiens
4-chloro-3-methylphenol
0.11
-
IC50: 0.11 mM, vs. 10 nM estradiol
Homo sapiens
4-Chlorophenol
0.13
-
IC50: 0.13 mM, vs. 10 nM estradiol
Homo sapiens
3-chlorophenol
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0007
-
IC50: 0.0007 mM, vs. 10 nM estradiol
Homo sapiens
2,3-dichlorophenol
0.0007
-
IC50: 0.0007 mM, vs. 10 nM estradiol
Homo sapiens
2,4-Dichlorophenol
0.0016
-
IC50: 0.0016 mM, vs. 10 nM estradiol
Homo sapiens
2,6-dichlorophenol
0.0022
-
IC50: 0.0022 mM, vs. 10 nM estradiol
Homo sapiens
2,5-dichlorophenol
0.0052
-
IC50: 0.0052 mM, vs. 10 nM estradiol
Homo sapiens
2-phenylphenol
0.013
-
IC50: 0.013 mM, vs. 10 nM estradiol
Homo sapiens
3,4-dichlorophenol
0.017
-
IC50: 0.017 mM, vs. 10 nM estradiol
Homo sapiens
3,5-dichlorophenol
0.02
-
IC50: 0.02 mM, vs. 10 nM estradiol
Homo sapiens
2-chlorophenol
0.024
-
IC50: 0.024 mM, vs. 10 nM estradiol
Homo sapiens
4-chloro-3-methylphenol
0.11
-
IC50: 0.11 mM, vs. 10 nM estradiol
Homo sapiens
4-Chlorophenol
0.13
-
IC50: 0.13 mM, vs. 10 nM estradiol
Homo sapiens
3-chlorophenol
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2,3-dichlorophenol
IC50: 0.0007 mM, vs. 10 nM estradiol
Homo sapiens
2,4-Dichlorophenol
IC50: 0.0007 mM, vs. 10 nM estradiol
Homo sapiens
2,5-dichlorophenol
IC50: 0.0022 mM, vs. 10 nM estradiol
Homo sapiens
2,6-dichlorophenol
IC50: 0.0016 mM, vs. 10 nM estradiol
Homo sapiens
2-chlorophenol
IC50: 0.02 mM, vs. 10 nM estradiol
Homo sapiens
2-phenylphenol
IC50: 0.0052 mM, vs. 10 nM estradiol
Homo sapiens
3,4-dichlorophenol
IC50: 0.013 mM, vs. 10 nM estradiol
Homo sapiens
3,5-dichlorophenol
IC50: 0.017 mM, vs. 10 nM estradiol
Homo sapiens
3-chlorophenol
IC50: 0.13 mM, vs. 10 nM estradiol
Homo sapiens
4-chloro-3-methylphenol
IC50: 0.024 mM, vs. 10 nM estradiol
Homo sapiens
4-Chlorophenol
IC50: 0.11 mM, vs. 10 nM estradiol
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3'-phosphoadenylylsulfate + estradiol
-
662863
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
Other publictions for EC 2.8.2.15
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737572
Maiti
Ethanol up-regulates phenol su ...
Rattus norvegicus
Arch. Physiol. Biochem.
121
68-74
2015
-
-
-
-
-
-
-
-
-
-
-
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1
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2
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2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
738098
Ou
Transcriptional regulation of ...
Homo sapiens
Drug Metab. Dispos.
42
1684-1689
2014
-
-
-
-
-
-
-
-
-
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1
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2
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2
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-
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-
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-
1
-
-
1
-
-
738099
Squirewell
Endoxifen and other metabolite ...
Homo sapiens
Drug Metab. Dispos.
42
1843-1850
2014
-
-
1
-
-
-
4
-
-
-
-
2
-
2
-
-
1
-
-
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2
-
-
-
-
-
-
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-
-
8
-
8
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1
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-
8
4
8
-
-
-
-
2
-
-
-
1
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-
-
2
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
738552
Huang
Estrogen-related receptor ERRa ...
Homo sapiens
J. Biochem. Mol. Toxicol.
28
32-38
2014
-
-
-
-
-
-
-
-
-
-
-
1
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1
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-
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1
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1
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1
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1
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1
-
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-
-
-
-
-
-
-
1
-
-
1
-
-
725980
Ou
Regulation of the human hydrox ...
Homo sapiens
Mol. Endocrinol.
27
106-115
2013
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
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-
-
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1
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3
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
726332
Yang
Hydroxysteroid sulfotransferas ...
Homo sapiens
PLoS ONE
8
e60853
2013
-
-
-
-
-
-
-
-
-
-
1
1
-
3
-
-
-
-
-
6
-
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1
1
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-
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-
-
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1
1
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6
-
-
1
1
-
-
-
-
-
-
-
-
2
2
2
2
-
-
738102
Falany
SULT2B1: unique properties and ...
Homo sapiens
Drug Metab. Rev.
45
388-400
2013
-
-
-
-
-
-
-
-
2
-
-
-
-
5
-
-
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-
11
-
-
5
-
-
-
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2
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11
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723910
Zhang
Cytosolic sulfotransferase 2B1 ...
Homo sapiens
Am. J. Physiol. Gastrointest. Liver Physiol.
303
G344-G355
2012
-
-
1
-
-
-
-
-
1
-
1
1
-
4
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
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-
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1
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-
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-
1
-
1
1
-
-
-
-
-
1
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-
1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
724113
Gulcan
Substrate inhibition in human ...
Homo sapiens
Arch. Biochem. Biophys.
507
232-240
2011
-
-
1
-
-
-
2
1
-
-
1
1
-
1
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
1
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-
-
-
1
-
-
-
-
-
2
1
1
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-
1
1
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1
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1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724741
Ekuase
Structure-activity relationshi ...
Homo sapiens
Chem. Res. Toxicol.
24
1720-1728
2011
-
-
1
-
-
-
15
8
-
-
1
8
-
1
-
-
1
-
-
-
-
-
8
1
-
-
-
-
-
-
-
-
-
-
15
-
-
1
-
-
-
-
15
15
-
8
-
-
1
8
-
-
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1
-
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8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724959
Kurogi
Mouse cytosolic sulfotransfera ...
Mus musculus
FEBS J.
277
3804-3811
2010
-
-
1
-
-
-
-
-
3
-
1
4
-
3
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-
-
-
-
3
-
4
1
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1
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3
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1
4
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3
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4
1
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1
1
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-
-
725045
Koizumi
Momoeda, M.; Hiroi, H.; Hosoka ...
Homo sapiens
Fertil. Steril.
93
1538-1544
2010
-
-
-
-
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2
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4
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4
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1
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1
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-
702138
Senggunprai
Inhibitory effects of kynureni ...
Homo sapiens, Mus musculus
Biochem. J.
422
455-462
2009
-
-
2
-
-
-
13
9
2
-
-
16
-
2
-
-
2
-
-
-
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16
-
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11
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2
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11
13
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9
2
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16
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2
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16
-
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-
706919
Shimada
Expression of a skin cholester ...
Mus musculus
Xenobiotica
38
1487-1499
2008
-
-
1
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-
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2
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1
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3
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1
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3
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1
1
1
1
-
-
673838
Seo
Xenobiotic- and vitamin D-resp ...
Mus musculus
Gene
386
218-223
2007
1
-
1
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1
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1
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1
-
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1
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675275
Fuda
Oxysterols are substrates for ...
Homo sapiens
J. Lipid Res.
48
1343-1352
2007
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1
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1
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1
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7
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1
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7
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676007
Echchgadda
The xenobiotic-sensing nuclear ...
Homo sapiens
Mol. Endocrinol.
21
2099-2111
2007
1
-
1
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1
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1
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1
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2
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677218
Chen
Human constitutive androstane ...
Homo sapiens
Toxicology
231
224-233
2007
-
-
1
-
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-
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1
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1
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1
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1
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673061
Liu
Hydroxylated polychlorinated b ...
Homo sapiens
Chem. Res. Toxicol.
19
1420-1425
2006
-
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1
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3
3
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2
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2
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2
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5
-
1
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1
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2
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1
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1
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1
3
2
3
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2
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2
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5
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1
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1
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673295
He
Characterization of proline-se ...
Homo sapiens
Drug Metab. Dispos.
34
1749-1755
2006
-
-
1
-
1
1
-
3
3
1
-
2
-
4
-
1
1
-
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Chenodeoxycholic acid-mediated ...
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673350
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Indirect regulation of human d ...
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Nuclear receptor interactions ...
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Sulfation of tibolone metaboli ...
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Identification of a novel estr ...
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Identification and immunohisto ...
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661577
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Heterotropic modulation of sul ...
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Chang
Identifying androsterone (ADT) ...
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Expression of cholesterol sulf ...
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663165
Marsolais
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Molecular and biochemical char ...
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Plant Sci.
166
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Steroid sulfatase and estrogen ...
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Am. J. Pathol.
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2003
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Suzuki
Estrogen sulfotransferase and ...
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63
2762-2770
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High metabolization of catecho ...
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Expression and characterizatio ...
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645736
Park
Testosterone sulfotransferase: ...
Cavia porcellus
Steroids
64
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Falany
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645728
Takikawa
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Identification and partial pur ...
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Gower
Sulphoconjugation of steroids ...
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645726
Singer
Enzymatic sulfation of steroid ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
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1982
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Adams
Enzymic synthesis of steroid s ...
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Biochim. Biophys. Acta
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1980
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645723
Adams
Enzymic synthesis of steroid s ...
Homo sapiens
Biochim. Biophys. Acta
567
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1979
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645722
Singer
Enzymatic sulfation of steroid ...
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5
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12
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1
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5
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1
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