BRENDA - Enzyme Database show
show all sequences of 2.8.2.15

Purification and characterization of human liver dehydroepiandrosterone sulphotransferase

Falany, C.N.; Vasquez, M.E.; Kalb, J.M.; Biochem. J. 260, 641-646 (1989)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
adenosine 3',5'-bisphosphate
-
Homo sapiens
pregnenolone
substrate inhibition
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0016
-
3beta-hydroxyandrost-5-ene-17-one
pH 7.5, ?
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
endoplasmic reticulum
-
Homo sapiens
5783
-
Golgi apparatus
-
Homo sapiens
5794
-
membrane
-
Homo sapiens
16020
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
68000
70000
gel filtration
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
human
-
Purification (Commentary)
Commentary
Organism
-
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.133
-
-
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3'-phosphoadenylylsulfate + 17beta-estradiol
estra-1,3,5(10)-triene-3,17alpha-diol
645729
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
r
3'-phosphoadenylylsulfate + 3alpha-hydroxy-5alpha-androstan-17-one
androsterone
645729
Homo sapiens
adenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate
androsterone sulfate
645729
Homo sapiens
r
3'-phosphoadenylylsulfate + 3beta-hydroxy-5alpha-androstan-17-one
epiandrosterone
645729
Homo sapiens
adenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate
-
645729
Homo sapiens
r
3'-phosphoadenylylsulfate + androst-5-ene-3beta,17beta-diol
-
645729
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
r
3'-phosphoadenylylsulfate + estrone
-
645729
Homo sapiens
adenosine 3',5'-bisphosphate + estrone sulfate
estra-1,3,5(10)-trien-17-one 3-sulfate
645729
Homo sapiens
r
3'-phosphoadenylylsulfate + etiocholanone
3alpha-hydroxy-5beta-androstan-17-one
645729
Homo sapiens
adenosine 3',5'-bisphosphate + etiocholanone sulfate
5beta-androstan-17-one 3-sulfate
645729
Homo sapiens
r
3'-phosphoadenylylsulfate + pregnenolone
-
645729
Homo sapiens
adenosine 3',5'-bisphosphate + pregnenolone sulfate
pregn-5-en-20-one 3-sulfate
645729
Homo sapiens
r
3'-phosphoadenylylsulfate + testosterone
17beta-hydroxyandrost-4-en-3-one
645729
Homo sapiens
adenosine 3',5'-bisphosphate + testosterone sulfate
androst-4-en-3-one 17-sulfate
645729
Homo sapiens
r
additional information
no activity towards p-nitrophenol or dopamine
645729
Homo sapiens
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
dimer
-
Homo sapiens
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.0016
-
adenosine 3',5'-bisphosphate
pH 7.5
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
adenosine 3',5'-bisphosphate
-
Homo sapiens
pregnenolone
substrate inhibition
Homo sapiens
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.0016
-
adenosine 3',5'-bisphosphate
pH 7.5
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0016
-
3beta-hydroxyandrost-5-ene-17-one
pH 7.5, ?
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
endoplasmic reticulum
-
Homo sapiens
5783
-
Golgi apparatus
-
Homo sapiens
5794
-
membrane
-
Homo sapiens
16020
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
68000
70000
gel filtration
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.133
-
-
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3'-phosphoadenylylsulfate + 17beta-estradiol
estra-1,3,5(10)-triene-3,17alpha-diol
645729
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
r
3'-phosphoadenylylsulfate + 3alpha-hydroxy-5alpha-androstan-17-one
androsterone
645729
Homo sapiens
adenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate
androsterone sulfate
645729
Homo sapiens
r
3'-phosphoadenylylsulfate + 3beta-hydroxy-5alpha-androstan-17-one
epiandrosterone
645729
Homo sapiens
adenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate
-
645729
Homo sapiens
r
3'-phosphoadenylylsulfate + androst-5-ene-3beta,17beta-diol
-
645729
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
r
3'-phosphoadenylylsulfate + estrone
-
645729
Homo sapiens
adenosine 3',5'-bisphosphate + estrone sulfate
estra-1,3,5(10)-trien-17-one 3-sulfate
645729
Homo sapiens
r
3'-phosphoadenylylsulfate + etiocholanone
3alpha-hydroxy-5beta-androstan-17-one
645729
Homo sapiens
adenosine 3',5'-bisphosphate + etiocholanone sulfate
5beta-androstan-17-one 3-sulfate
645729
Homo sapiens
r
3'-phosphoadenylylsulfate + pregnenolone
-
645729
Homo sapiens
adenosine 3',5'-bisphosphate + pregnenolone sulfate
pregn-5-en-20-one 3-sulfate
645729
Homo sapiens
r
3'-phosphoadenylylsulfate + testosterone
17beta-hydroxyandrost-4-en-3-one
645729
Homo sapiens
adenosine 3',5'-bisphosphate + testosterone sulfate
androst-4-en-3-one 17-sulfate
645729
Homo sapiens
r
additional information
no activity towards p-nitrophenol or dopamine
645729
Homo sapiens
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
-
Homo sapiens
Other publictions for EC 2.8.2.15
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737572
Maiti
Ethanol up-regulates phenol su ...
Rattus norvegicus
Arch. Physiol. Biochem.
121
68-74
2015
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
738098
Ou
Transcriptional regulation of ...
Homo sapiens
Drug Metab. Dispos.
42
1684-1689
2014
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
738099
Squirewell
Endoxifen and other metabolite ...
Homo sapiens
Drug Metab. Dispos.
42
1843-1850
2014
-
-
1
-
-
-
4
-
-
-
-
2
-
2
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
8
-
8
-
-
1
-
-
-
-
8
4
8
-
-
-
-
2
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738552
Huang
Estrogen-related receptor ERRa ...
Homo sapiens
J. Biochem. Mol. Toxicol.
28
32-38
2014
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
725980
Ou
Regulation of the human hydrox ...
Homo sapiens
Mol. Endocrinol.
27
106-115
2013
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
726332
Yang
Hydroxysteroid sulfotransferas ...
Homo sapiens
PLoS ONE
8
e60853
2013
-
-
-
-
-
-
-
-
-
-
1
1
-
3
-
-
-
-
-
6
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
6
-
-
1
1
-
-
-
-
-
-
-
-
2
2
2
2
-
-
738102
Falany
SULT2B1: unique properties and ...
Homo sapiens
Drug Metab. Rev.
45
388-400
2013
-
-
-
-
-
-
-
-
2
-
-
-
-
5
-
-
-
-
-
11
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
11
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723910
Zhang
Cytosolic sulfotransferase 2B1 ...
Homo sapiens
Am. J. Physiol. Gastrointest. Liver Physiol.
303
G344-G355
2012
-
-
1
-
-
-
-
-
1
-
1
1
-
4
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
724113
Gulcan
Substrate inhibition in human ...
Homo sapiens
Arch. Biochem. Biophys.
507
232-240
2011
-
-
1
-
-
-
2
1
-
-
1
1
-
1
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
2
1
1
-
-
1
1
-
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724741
Ekuase
Structure-activity relationshi ...
Homo sapiens
Chem. Res. Toxicol.
24
1720-1728
2011
-
-
1
-
-
-
15
8
-
-
1
8
-
1
-
-
1
-
-
-
-
-
8
1
-
-
-
-
-
-
-
-
-
-
15
-
-
1
-
-
-
-
15
15
-
8
-
-
1
8
-
-
-
1
-
-
-
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724959
Kurogi
Mouse cytosolic sulfotransfera ...
Mus musculus
FEBS J.
277
3804-3811
2010
-
-
1
-
-
-
-
-
3
-
1
4
-
3
-
-
-
-
-
-
3
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
1
4
-
-
-
-
-
-
3
-
4
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
725045
Koizumi
Momoeda, M.; Hiroi, H.; Hosoka ...
Homo sapiens
Fertil. Steril.
93
1538-1544
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
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-
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-
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-
-
-
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-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
702138
Senggunprai
Inhibitory effects of kynureni ...
Homo sapiens, Mus musculus
Biochem. J.
422
455-462
2009
-
-
2
-
-
-
13
9
2
-
-
16
-
2
-
-
2
-
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
11
-
-
2
-
-
-
-
11
13
-
9
2
-
-
16
-
-
-
2
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706919
Shimada
Expression of a skin cholester ...
Mus musculus
Xenobiotica
38
1487-1499
2008
-
-
1
-
-
-
-
-
2
-
-
1
-
3
-
-
1
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
1
-
3
-
-
1
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
673838
Seo
Xenobiotic- and vitamin D-resp ...
Mus musculus
Gene
386
218-223
2007
1
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675275
Fuda
Oxysterols are substrates for ...
Homo sapiens
J. Lipid Res.
48
1343-1352
2007
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676007
Echchgadda
The xenobiotic-sensing nuclear ...
Homo sapiens
Mol. Endocrinol.
21
2099-2111
2007
1
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677218
Chen
Human constitutive androstane ...
Homo sapiens
Toxicology
231
224-233
2007
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
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673061
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Hydroxylated polychlorinated b ...
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Chem. Res. Toxicol.
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673295
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Characterization of proline-se ...
Homo sapiens
Drug Metab. Dispos.
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1
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1
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Miyata
Chenodeoxycholic acid-mediated ...
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673350
Huang
Indirect regulation of human d ...
Homo sapiens
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147
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Nuclear receptor interactions ...
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Wang
Sulfation of tibolone metaboli ...
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Miyata
Role for enhanced faecal excre ...
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Identification of a novel estr ...
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661253
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Identification and immunohisto ...
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Sinclair
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11
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Different subcellular localiza ...
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661577
Cui
Heterotropic modulation of sul ...
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Chang
Identifying androsterone (ADT) ...
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Expression of cholesterol sulf ...
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663165
Marsolais
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Molecular and biochemical char ...
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Plant Sci.
166
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Steroid sulfatase and estrogen ...
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Am. J. Pathol.
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2003
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645741
Suzuki
Estrogen sulfotransferase and ...
Homo sapiens
Cancer Res.
63
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Expression and characterizatio ...
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645736
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Testosterone sulfotransferase: ...
Cavia porcellus
Steroids
64
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Identification of a new adult ...
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Biochem. Biophys. Res. Commun.
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1994
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Borthwick
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645729
Falany
Purification and characterizat ...
Homo sapiens
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1989
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645728
Takikawa
Purification of a 32.5 kDa mon ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
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1986
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645727
Sugiyama
Identification and partial pur ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
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645725
Gower
Sulphoconjugation of steroids ...
Sus scrofa
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507-510
1982
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645726
Singer
Enzymatic sulfation of steroid ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Biochim. Biophys. Acta
700
110-117
1982
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645724
Adams
Enzymic synthesis of steroid s ...
Homo sapiens
Biochim. Biophys. Acta
615
275-278
1980
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14
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14
1
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645723
Adams
Enzymic synthesis of steroid s ...
Homo sapiens
Biochim. Biophys. Acta
567
144-153
1979
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645722
Singer
Enzymatic sulfation of steroid ...
Rattus norvegicus
Can. J. Biochem.
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1028-1035
1978
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5
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12
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5
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