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Literature summary for 2.8.2.14 extracted from

  • Dawson, P.; Setchell, K.
    Will the real bile acid sulfotransferase please stand up? Identification of Sult2a8 as a major hepatic bile acid sulfonating enzyme in mice1 (2017), J. Lipid Res., 58, 1033-1035 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.14

Cloned(Commentary)

Cloned (Comment) Organism
gene Sult2a8 is localized to chromosome 7, embedded in a 0.9 Mb region harboring the cluster of Sult2a genes (Sult2a5-Sult2a2-Sult2a1-Sult2a4-Sult2a3-Sult2a6-Sult2a8-Sult2a7), as well as several Sult2a pseudogenes Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
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 Mus musculus 5829
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + alpha-muricholic acid Mus musculus
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 adenosine 3',5'-bisphosphate + alpha-muricholate 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + chenodeoxycholic acid Mus musculus
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 adenosine 3',5'-bisphosphate + chenodeoxycholate 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + cholic acid Mus musculus
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 adenosine 3',5'-bisphosphate + cholate 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + tauro-alpha-muricholic acid Mus musculus
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 adenosine 3',5'-bisphosphate + tauro-alpha-muricholate 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + taurochenodeoxycholic acid Mus musculus
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 adenosine 3',5'-bisphosphate + taurochenodeoxycholate 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + taurocholic acid Mus musculus
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 adenosine 3',5'-bisphosphate + taurocholate 3-sulfate
-
 ?
additional information Mus musculus activity of recombinant Sult2a8 confirms that the enzyme is a bile acid sulfotransferase with high activity toward 7alpha-hydroxylated bile acids such as taurocholic acid, cholic acid, taurochenodeoxycholic acid, chenodeoxycholic acid, tauro-alpha-muricholic acid, and alpha-muricholic acid, but little activity toward bile acids lacking a 7alpha-hydroxy group, such as deoxycholic acid or lithocholic acid. Sult2a8 is highly specific for 7alpha-hydroxylated bile acids/salts and exhibits little or no ability to sulfonate other prototypic SULT substrates, including steroids (androsterone, DHEA, prenenolone, and cholesterol), phenols, catecholamines, or thyroid hormones ?
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Organism

Organism UniProt Comment Textmining
Mus musculus Q8BGL3
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Source Tissue

Source Tissue Comment Organism Textmining
liver the expression of Sult2a8 in male livers is higher compared to female livers Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + alpha-muricholic acid
-
 Mus musculus adenosine 3',5'-bisphosphate + alpha-muricholate 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + chenodeoxycholic acid
-
 Mus musculus adenosine 3',5'-bisphosphate + chenodeoxycholate 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + cholic acid
-
 Mus musculus adenosine 3',5'-bisphosphate + cholate 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + tauro-alpha-muricholic acid
-
 Mus musculus adenosine 3',5'-bisphosphate + tauro-alpha-muricholate 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + taurochenodeoxycholic acid
-
 Mus musculus adenosine 3',5'-bisphosphate + taurochenodeoxycholate 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + taurocholic acid
-
 Mus musculus adenosine 3',5'-bisphosphate + taurocholate 3-sulfate
-
 ?
additional information activity of recombinant Sult2a8 confirms that the enzyme is a bile acid sulfotransferase with high activity toward 7alpha-hydroxylated bile acids such as taurocholic acid, cholic acid, taurochenodeoxycholic acid, chenodeoxycholic acid, tauro-alpha-muricholic acid, and alpha-muricholic acid, but little activity toward bile acids lacking a 7alpha-hydroxy group, such as deoxycholic acid or lithocholic acid. Sult2a8 is highly specific for 7alpha-hydroxylated bile acids/salts and exhibits little or no ability to sulfonate other prototypic SULT substrates, including steroids (androsterone, DHEA, prenenolone, and cholesterol), phenols, catecholamines, or thyroid hormones Mus musculus ?
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Synonyms

Synonyms Comment Organism
SULT2A8
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus SUlt2A8 is a PPARalpha-regulated gene additional information

General Information

General Information Comment Organism
physiological function Sult2a8 is a major hepatic bile acid sulfonating enzyme in mice Mus musculus