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Literature summary for 2.8.2.14 extracted from
- The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase (2007), Mol. Endocrinol., 21, 2099-2111.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| constitutive androstane receptor | 3.5fold induction of SULT2A1 mRNAs in human cell lines of enterohepatic origin, such as Caco-2 intestinal cells and HepG2 hepatoma cells transfected with the CAR plasmid | Homo sapiens | |
| pregnane X receptor | 1.7fold induction of SULT2A1 mRNAs in human cell lines of enterohepatic origin, such as Caco-2 intestinal cells and HepG2 hepatoma cells transfected with the PXR plasmid | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + glycolithocholate | Homo sapiens | the enzyme mediates catalytic conversion of hydroxysteroids, bile acids, and certain clinical drugs to water-soluble sulfated metabolites | adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q06520 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal cortex | - |
Homo sapiens | - |
| Caco-2 cell | - |
Homo sapiens | - |
| Hep-G2 cell | - |
Homo sapiens | - |
| intestine | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + glycolithocholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + glycolithocholate | the enzyme mediates catalytic conversion of hydroxysteroids, bile acids, and certain clinical drugs to water-soluble sulfated metabolites | Homo sapiens | adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| steroid-/bile acid-sulfotransferase | - |
Homo sapiens |
| SULT2A1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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