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Literature summary for 2.8.2.14 extracted from
- Bile salt sulfotransferase (1981), Methods Enzymol., 77, 213-218.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenosine-3',5'-diphosphate | - |
Cavia porcellus |  |
| adenosine-3',5'-diphosphate | - |
Homo sapiens | |
| adenosine-3',5'-diphosphate | - |
Rattus norvegicus | |
| ATP | - |
Cavia porcellus | |
| ATP | - |
Rattus norvegicus | |
| Cu2+ | - |
Homo sapiens | |
| Cu2+ | - |
Rattus norvegicus | |
| EDTA | - |
Cavia porcellus | |
| EDTA | - |
Rattus norvegicus | |
| Fe2+ | - |
Homo sapiens | |
| Fe2+ | - |
Rattus norvegicus | |
| iodoacetate | - |
Cavia porcellus | |
| iodoacetate | - |
Rattus norvegicus | |
| NaN3 | - |
Cavia porcellus | |
| NaN3 | - |
Rattus norvegicus | |
| p-chloromercuribenzoate | - |
Cavia porcellus | |
| p-chloromercuribenzoate | - |
Homo sapiens | |
| p-chloromercuribenzoate | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.008 | - |
3'-phosphoadenylylsulfate | pH 6.5, 37°C | Rattus norvegicus | |
| 0.05 | - |
taurolithocholate | pH 6.5, 37°C | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Mesocricetus auratus | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | - |
Homo sapiens | |
| Co2+ | - |
Rattus norvegicus | |
| Mg2+ | - |
Cavia porcellus | |
| Mg2+ | - |
Homo sapiens | |
| Mg2+ | - |
Rattus norvegicus | |
| Mn2+ | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 130000 | - |
- |
Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + taurolithocholate | Cavia porcellus | - |
adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + taurolithocholate | Rattus norvegicus | - |
adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
guinea pig | - |
| Homo sapiens | - |
human | - |
| Mesocricetus auratus | - |
- |
- |
| Oryctolagus cuniculus | - |
rabbit | - |
| Rattus norvegicus | - |
rat | - |
| Sus scrofa | - |
pig | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Mesocricetus auratus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Cavia porcellus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Sus scrofa | - |
| liver | - |
Oryctolagus cuniculus | - |
| liver | - |
Mesocricetus auratus | - |
| small intestine | - |
Mesocricetus auratus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0164 | - |
- |
Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, crude enzyme may be stored for several months without loss of enzyme activity | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + taurolithocholate | - |
Cavia porcellus | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + taurolithocholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + glycolithocholate | - |
Cavia porcellus | adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + glycolithocholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + glycolithocholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + glycolithocholate | - |
Mesocricetus auratus | adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + lithocholate | - |
Cavia porcellus | adenosine 3',5'-bisphosphate + lithocholate 3-sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + lithocholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + lithocholate 3-sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + lithocholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + lithocholate 3-sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + lithocholate | - |
Mesocricetus auratus | adenosine 3',5'-bisphosphate + lithocholate 3-sulfate | - |
? | |
| additional information | - |
Homo sapiens | ? | - |
? | |
| additional information | purified enzyme does not react with estrone, estradiol, testosterone, dehydroepiandrosterone, cholesterol, or cortisol | Rattus norvegicus | ? | - |
? | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Rattus norvegicus | - |
- |
5.3 |
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