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Literature summary for 2.8.2.14 extracted from
- Enzymatic sulfation of bile salts. Partial purification and characterization of an enzyme from rat liver that catalyzes the sulfation of bile salts (1977), Biochim. Biophys. Acta, 480, 219-227.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenosine-3',5'-diphosphate | - |
Rattus norvegicus |  |
| additional information | EDTA and NaF exhibits slight inhibitory effect | Rattus norvegicus | |
| p-chloromercuribenzoate | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.008 | - |
3'-phosphoadenylylsulfate | - |
Rattus norvegicus | |
| 0.05 | - |
taurolithocholate | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 130000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + taurolithocholate | Rattus norvegicus | - |
adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| additional information | not detectable in brain, lung, heart, spleen, intestinal mucosa or red blood cells | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + taurolithocholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + lithocholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + lithocholate 3-sulfate | - |
? | |
| additional information | rate of sulfation is higher with conjugated bile salts than with unconjugated | Rattus norvegicus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Rattus norvegicus |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Rattus norvegicus | isoelectric focusing electrophoresis, method originally described by Svensson, maintained at 0°C | - |
5.3 |
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